Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa

Malaria Journal

Table 5 Haplotype frequencies of the FcγRIIa 131 R/H*, CRP -286 C/T/A, CRP -717 C/T and CRP +1444 T/C

Mali
		FcγRIIa131R/H CRP-286C/T/A		CRP-286C/T/A CRP-717C/T	CRP-286C/T/A CRP+1444T/C	FcγRIIa131R/H CRP-286C/T/A CRP-717C/T		CRP-286C/T/A CRP-717C/T CRP+1444T/C	FcγRIIa131R/H CRP-286C/T/A CRP+1444T/C		FcγRIIa131R/H CRP-286C/T/A CRP-717C/T CRP+1444T/C
Reference haplotype		HA		AC	AC	HAC		ACC	HAC		HACC
	N	HA	RA	AT	AC	HAT	RAT	ATC	HAC		HATC	RATC
Non-Fulani	159	0.20	0.19	0.39	0.39	0.20	0.19	0.39	0.21		0.20	0.19
Fulani	164	0.09	0.09	0.18	0.18	0.09	0.09	0.18	0.7		0.09	0.09
OR		2.57	2.26	2.79	2.79	2.58	2.29	2.79	3.6		2.6	2.28
P-value		0.0001	0.0006	1 × 10^-8	1 × 10^-8	0.0001	0.0005	1 × 10^-8	1 × 10^-8		0.0001	0.0004
Sudan
	N	HA	RA	AT	AC	HAT	RAT	ATC	HAT	RAC	HATC	RATC
Non-Fulani	100	0.21	0.18	0.41	0.41	0.22	0.18	0.41	0.25	0.17	0.24	0.17
Fulani	225	0.13	0.08	0.21	0.21	0.13	0.08	0.21	0.12	0.08	0.13	0.09
OR		1.88	2.52	2.65	2.66	2.05	2.6	2.65	2.33	2.24	2.19	2.42
P-value		0.007	0.0003	0.0001	0.0001	0.03	0.006	0.0001	0.005	0.03	0.01	0.02

* The data for the FcγRIIa 131 R/H from Mali was obtained from Israelsson et al [7], and from Sudan from Nasr et al [30]

ISSN: 1475-2875