| | Dd2Nm | HB3 | FCR3 | 78GR |
|---|
OHCT-IC
50
| 85 ± 36.1 | 38 ± 9.7 | 93 ± 48.7 | 3.9 ± 0.5 |
-IC
90
| 422 ± 27.4 | 523 ± 310 | 407 ± 150 | 17.4 ± 0.9 |
Chlor-IC
50
| 85 ± 22.5 | | 181 ± 92.8 | |
-IC
90
| 546 ± 69.1 | < 20 | 524 ± 150.3 | |
Artem-IC
50
| - | - | - | 4.2 ± 0.4 |
-IC
90
| - | - | - | 18.1 ± 1.0 |
- * P. falciparum clones, two chloroquine resistant clones, Dd2Nm and FCR3, one chloroquine sensitive clone, HB3, and the artemisinin resistant clone 78 GR were incubated with five concentrations of OHCT for 48 h. Percent parasitaemia in 9,500 infected human erythrocytes was estimated by microscopic observation of Giemsa-stained blood smears and by measurement of p(LDH). IC50 and IC90 values (nM) represent the mean ± SE of 3 experiments (vehicle and 5 duplicate concentrations per experiment).
