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Table 1 Inhibition of Plasmodium survival by OHCT (nM)*

From: Antimalarial activity of a cis-terpenone

  Dd2Nm HB3 FCR3 78GR
OHCT-IC 50 85 ± 36.1 38 ± 9.7 93 ± 48.7 3.9 ± 0.5
-IC 90 422 ± 27.4 523 ± 310 407 ± 150 17.4 ± 0.9
Chlor-IC 50 85 ± 22.5   181 ± 92.8  
-IC 90 546 ± 69.1 < 20 524 ± 150.3  
Artem-IC 50 - - - 4.2 ± 0.4
-IC 90 - - - 18.1 ± 1.0
  1. * P. falciparum clones, two chloroquine resistant clones, Dd2Nm and FCR3, one chloroquine sensitive clone, HB3, and the artemisinin resistant clone 78 GR were incubated with five concentrations of OHCT for 48 h. Percent parasitaemia in 9,500 infected human erythrocytes was estimated by microscopic observation of Giemsa-stained blood smears and by measurement of p(LDH). IC50 and IC90 values (nM) represent the mean ± SE of 3 experiments (vehicle and 5 duplicate concentrations per experiment).