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Table 2 Univariate and multivariate analysis for factors predicting treatment failure

From: Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda

   Univariate Multivariate
Variable Number of treatment failures Odds ratio> 95% CI p-value Odds ratio 95%CI p-value
Type of seizure        
Generalized seizure 56 - -   1 - -
Focal seizure 19 3.47 1.57–7.67 <0.001 3.21 1.42–7.25 0.005
Form of disease        
Non-cerebral malaria 52 - -   1 - -
Cerebral malaria 23 2.14 1.10–4.15 0.02 2.43 1.20–4.91 0.01
Recent use of diazepam        
No 65 - -   a   
Yes 10 1.88 0.75–4.70 0.16 a   
Pre-treatment blood glucose level        
< 200 mg/dl 62 1 -   1   
≥ 200 mg/dl 13 2.85 1.16–6.95 0.01 2.84 1.11–7.20 0.02
Age        
> 11 months 54 1 -   1   
< 12 months 21 1.88 0.96–3.67 0.06 1.99 0.96–4.13 0.06
Number of seizures        
< 3 38 1 -   a   
≥ 3 37 1.18 0.80–2.56 0.21 a   
Treatment received        
Midazolam 37 1 -   1   
Diazepam 38 1.21 0.69–2.11 0.50 1.40 0.77–2.56 0.26
Unconscious prior to onset of seizure        
No 35 1 -   a   
Yes 37 1.60 0.90–2.85 0.11 a   
  1. a Not included in the final model.