Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda

Table 2 Univariate and multivariate analysis for factors predicting treatment failure

		Univariate			Multivariate
Variable	Number of treatment failures	Odds ratio>	95% CI	p-value	Odds ratio	95%CI	p-value
Type of seizure
Generalized seizure	56	-	-		1	-	-
Focal seizure	19	3.47	1.57–7.67	<0.001	3.21	1.42–7.25	0.005
Form of disease
Non-cerebral malaria	52	-	-		1	-	-
Cerebral malaria	23	2.14	1.10–4.15	0.02	2.43	1.20–4.91	0.01
Recent use of diazepam
No	65	-	-		^a
Yes	10	1.88	0.75–4.70	0.16	^a
Pre-treatment blood glucose level
< 200 mg/dl	62	1	-		1
≥ 200 mg/dl	13	2.85	1.16–6.95	0.01	2.84	1.11–7.20	0.02
Age
> 11 months	54	1	-		1
< 12 months	21	1.88	0.96–3.67	0.06	1.99	0.96–4.13	0.06
Number of seizures
< 3	38	1	-		^a
≥ 3	37	1.18	0.80–2.56	0.21	^a
Treatment received
Midazolam	37	1	-		1
Diazepam	38	1.21	0.69–2.11	0.50	1.40	0.77–2.56	0.26
Unconscious prior to onset of seizure
No	35	1	-		^a
Yes	37	1.60	0.90–2.85	0.11	^a

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