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Table 1 Blood schizontocidal activity of 6-SA, as measured against Plasmodium berghei in mice

From: Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice

  Dose 4-day test Repository activity
Compound/Drug (mg/kg/day) Average % parasitaemia Average % suppression Average % parasitaemia Average % suppression
6-SA 5 43.4 ± 0.25* 25.4 34.3 ± 0.37* 41.0
  10 21.5 ± 0.34* 63.0 17.4 ± 0.28* 70.1
  25 19.3 ± 0.09* 66.8 10.4 ± 0.09* 82.1
Chloroquine 5 6.4 ± 0.13* 89.0 ND ND
Pyrimethamine 1.2 ND*** ND 4.9 ± 0.32* 91.5
Control (S.T.**) 0.2 ml 58.2 ± 0.23 - 4.9 ± 0.32* -
  1. * Data are expressed as mean ± for five animals per group when compared with control. P < 0.05.
  2. ** S.T.: saline containing 0.5% Tween-80
  3. *** ND: Not determined.