Table 1 Blood schizontocidal activity of 6-SA, as measured against Plasmodium berghei in mice
From: Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice
Dose | 4-day test | Repository activity | |||
|---|---|---|---|---|---|
Compound/Drug | (mg/kg/day) | Average % parasitaemia | Average % suppression | Average % parasitaemia | Average % suppression |
6-SA | 5 | 43.4 ± 0.25* | 25.4 | 34.3 ± 0.37* | 41.0 |
10 | 21.5 ± 0.34* | 63.0 | 17.4 ± 0.28* | 70.1 | |
25 | 19.3 ± 0.09* | 66.8 | 10.4 ± 0.09* | 82.1 | |
Chloroquine | 5 | 6.4 ± 0.13* | 89.0 | ND | ND |
Pyrimethamine | 1.2 | ND*** | ND | 4.9 ± 0.32* | 91.5 |
Control (S.T.**) | 0.2 ml | 58.2 ± 0.23 | - | 4.9 ± 0.32* | - |