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Table 1 Baseline and disease characteristics in the included population

From: Safety of epoietin beta-quinine drug combination in children with cerebral malaria in Mali

 

Demographics and Disease Characteristics

Statistical analysis

 

Intention to treat

(n = 35)

Surviving patients

(n = 28)

Deceased patients

(n = 7)

p-value surviving vs deceased

Baseline Characteristics:

Mean ± standard deviation (range)

Student t -test

Sex ratio (M/F)

1.7 (22/13)

2.1 (19/9)

0.75 (3/4)

 

Age, years

6.3 ± 2.5 (2–12)

6.2 ± 2.7 (2–12)

6.7 ± 2.4 (3–9)

.60

Weight, kg

19.5 ± 6.9 (10–35)

19.7 ± 7.5 (10–35)

18.9 ± 6.0 (11–26)

.62

Temperature,°C

38.6 ± 1.3 (36.2–40.6)

38.7 ± 1.4 (36.2–40.6)

37.8 ± 1.0 (36.6–39.6)

.08

Clinic day 1:

Patient ratio (%)

Fisher F -test

Blantyre score = 1

17/35 (49%)

12/28 (43%)

5/7 (71%)

.32

Blantyre score = 2

18/35 (51%)

16/28 (57%)

2/7 (29%)

 

≥ 1 seizure

23/35 (66%)

17/28 (61%)

6/7 (85%)

.16

Deep breathing

7/35 (20%)

4/28 (14%)

3/7 (42%)

.06

Haemoglobinuria

7/35 (20%)

6/28 (21%)

1/7 (14%)

1

Jaundice

4/35 (11%)

4/28 (14%)

0/7 (0%)

.55

Biological values day 1

Mean ± standard deviation (range)

Student t -test

SaO2, %

91.0 ± 8.7 (73–98)

89.8 ± 9.4 (73–98)

95.1 ± 3.5 (88.7–98)

.10

asexual

43,000 ± 62,000

45,000 ± 46,000

37,000 ± 54,000

.85

P. falciparum/μL

(200–250,000)

(200–250,000)

(625–140,000)

 

Blood pH

7.29 ± 0.1 (7.1–7.43)

7.3 ± 0.1 (7.2–7.4)

7.3 ± 0.2 (7.1–7.4)

.72

Blood Lactates, mmol/L

6.0 ± 3.6 (1.4–15.4)

5.8 ± 3.3 (1.4–15.4)

6.3 ± 3.6 (2–11.7)

.78

Haemoglobin, g/dL

9.4 ± 1.4 (7.0–12.4)

9.6 ± 1.4 (7.0–12.4)

9.0 ± 1.2 (7.1–10.3)

.32

Plasma glucose, mmol/L

6.4 ± 3.6 (0.8–19.4)

6.3 ± 2.3 (1.1–11.3)

7.8 ± 6.1 (1.25–19.4)

.54

Plasma creatinin, μmol/L

57 ± 28 (21–130)

58.4 ± 26.0 (29–130)

36.7 ± 14.8 (21–60)

.02

ALAT, IU/L

87 ± 129 (7–600)

100 ± 150(7–600)

47 ± 18 (22–71)

.11

  1. Clinical and biological data were gathered at the time of admission. Included patients were stratified according to the primary end-point outcome (surviving or died patients on day six post admission). Student t-test or Fisher F-test were used to compare the two groups when appropriate.