From: Safety of epoietin beta-quinine drug combination in children with cerebral malaria in Mali
Demographics and Disease Characteristics | Statistical analysis | |||
---|---|---|---|---|
Intention to treat (n = 35) | Surviving patients (n = 28) | Deceased patients (n = 7) | p-value surviving vs deceased | |
Baseline Characteristics: | Mean ± standard deviation (range) | Student t -test | ||
Sex ratio (M/F) | 1.7 (22/13) | 2.1 (19/9) | 0.75 (3/4) | |
Age, years | 6.3 ± 2.5 (2–12) | 6.2 ± 2.7 (2–12) | 6.7 ± 2.4 (3–9) | .60 |
Weight, kg | 19.5 ± 6.9 (10–35) | 19.7 ± 7.5 (10–35) | 18.9 ± 6.0 (11–26) | .62 |
Temperature,°C | 38.6 ± 1.3 (36.2–40.6) | 38.7 ± 1.4 (36.2–40.6) | 37.8 ± 1.0 (36.6–39.6) | .08 |
Clinic day 1: | Patient ratio (%) | Fisher F -test | ||
Blantyre score = 1 | 17/35 (49%) | 12/28 (43%) | 5/7 (71%) | .32 |
Blantyre score = 2 | 18/35 (51%) | 16/28 (57%) | 2/7 (29%) | |
≥ 1 seizure | 23/35 (66%) | 17/28 (61%) | 6/7 (85%) | .16 |
Deep breathing | 7/35 (20%) | 4/28 (14%) | 3/7 (42%) | .06 |
Haemoglobinuria | 7/35 (20%) | 6/28 (21%) | 1/7 (14%) | 1 |
Jaundice | 4/35 (11%) | 4/28 (14%) | 0/7 (0%) | .55 |
Biological values day 1 | Mean ± standard deviation (range) | Student t -test | ||
SaO2, % | 91.0 ± 8.7 (73–98) | 89.8 ± 9.4 (73–98) | 95.1 ± 3.5 (88.7–98) | .10 |
asexual | 43,000 ± 62,000 | 45,000 ± 46,000 | 37,000 ± 54,000 | .85 |
P. falciparum/μL | (200–250,000) | (200–250,000) | (625–140,000) | |
Blood pH | 7.29 ± 0.1 (7.1–7.43) | 7.3 ± 0.1 (7.2–7.4) | 7.3 ± 0.2 (7.1–7.4) | .72 |
Blood Lactates, mmol/L | 6.0 ± 3.6 (1.4–15.4) | 5.8 ± 3.3 (1.4–15.4) | 6.3 ± 3.6 (2–11.7) | .78 |
Haemoglobin, g/dL | 9.4 ± 1.4 (7.0–12.4) | 9.6 ± 1.4 (7.0–12.4) | 9.0 ± 1.2 (7.1–10.3) | .32 |
Plasma glucose, mmol/L | 6.4 ± 3.6 (0.8–19.4) | 6.3 ± 2.3 (1.1–11.3) | 7.8 ± 6.1 (1.25–19.4) | .54 |
Plasma creatinin, μmol/L | 57 ± 28 (21–130) | 58.4 ± 26.0 (29–130) | 36.7 ± 14.8 (21–60) | .02 |
ALAT, IU/L | 87 ± 129 (7–600) | 100 ± 150(7–600) | 47 ± 18 (22–71) | .11 |