Skip to main content

Table 1 Baseline and disease characteristics in the included population

From: Safety of epoietin beta-quinine drug combination in children with cerebral malaria in Mali

  Demographics and Disease Characteristics Statistical analysis
  Intention to treat
(n = 35)
Surviving patients
(n = 28)
Deceased patients
(n = 7)
p-value surviving vs deceased
Baseline Characteristics: Mean ± standard deviation (range) Student t -test
Sex ratio (M/F) 1.7 (22/13) 2.1 (19/9) 0.75 (3/4)  
Age, years 6.3 ± 2.5 (2–12) 6.2 ± 2.7 (2–12) 6.7 ± 2.4 (3–9) .60
Weight, kg 19.5 ± 6.9 (10–35) 19.7 ± 7.5 (10–35) 18.9 ± 6.0 (11–26) .62
Temperature,°C 38.6 ± 1.3 (36.2–40.6) 38.7 ± 1.4 (36.2–40.6) 37.8 ± 1.0 (36.6–39.6) .08
Clinic day 1: Patient ratio (%) Fisher F -test
Blantyre score = 1 17/35 (49%) 12/28 (43%) 5/7 (71%) .32
Blantyre score = 2 18/35 (51%) 16/28 (57%) 2/7 (29%)  
≥ 1 seizure 23/35 (66%) 17/28 (61%) 6/7 (85%) .16
Deep breathing 7/35 (20%) 4/28 (14%) 3/7 (42%) .06
Haemoglobinuria 7/35 (20%) 6/28 (21%) 1/7 (14%) 1
Jaundice 4/35 (11%) 4/28 (14%) 0/7 (0%) .55
Biological values day 1 Mean ± standard deviation (range) Student t -test
SaO2, % 91.0 ± 8.7 (73–98) 89.8 ± 9.4 (73–98) 95.1 ± 3.5 (88.7–98) .10
asexual 43,000 ± 62,000 45,000 ± 46,000 37,000 ± 54,000 .85
P. falciparum/μL (200–250,000) (200–250,000) (625–140,000)  
Blood pH 7.29 ± 0.1 (7.1–7.43) 7.3 ± 0.1 (7.2–7.4) 7.3 ± 0.2 (7.1–7.4) .72
Blood Lactates, mmol/L 6.0 ± 3.6 (1.4–15.4) 5.8 ± 3.3 (1.4–15.4) 6.3 ± 3.6 (2–11.7) .78
Haemoglobin, g/dL 9.4 ± 1.4 (7.0–12.4) 9.6 ± 1.4 (7.0–12.4) 9.0 ± 1.2 (7.1–10.3) .32
Plasma glucose, mmol/L 6.4 ± 3.6 (0.8–19.4) 6.3 ± 2.3 (1.1–11.3) 7.8 ± 6.1 (1.25–19.4) .54
Plasma creatinin, μmol/L 57 ± 28 (21–130) 58.4 ± 26.0 (29–130) 36.7 ± 14.8 (21–60) .02
ALAT, IU/L 87 ± 129 (7–600) 100 ± 150(7–600) 47 ± 18 (22–71) .11
  1. Clinical and biological data were gathered at the time of admission. Included patients were stratified according to the primary end-point outcome (surviving or died patients on day six post admission). Student t-test or Fisher F-test were used to compare the two groups when appropriate.