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Table 2 Variations of fever, parasitaemia and haemoglobin over the time in the studies in Boende and Kabal

From: Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies

Characteristics

N

Boende

Kabalo

SP

107

AQ

106

AS+SP

91

AS+AQ

90

p

SP

60

AS+SP

62

AS+AQ

58

p

Proportion febrile d1 (%)

20/106

(18.7)

9/105

(8.5)

8/91

(8.8)

5/89

(5.6)

0.01

9/59

(15.3)

5/62

(8.1)

5/58

(8.6)

0.37

Proportion febrile d2 (%)

21/103

(20.4)

3/105

(2.8)

3/91

(3.3)

2/87

(2.2)

<0.001

13/58

(22.4)

1/62

(1.6)

1/58

(1.7)

<0.001

Proportion parasitaemic d2(%)

84/103

(81.5)

90/105

(85.7)

60/91

(65.9)

56/87

(64.4)

<0.001

35/58

(60.3)

8/62

(12.9)

9/58

(15.5)

<0.001

Proportion parasitaemic d7(%)

12/97

(11.4)

6/98

(6.1)

25/89

(28.1)

25/85

(29.4)

<0.001

5/51

(9.8)

7/60

(11.7)

1/54

(1.8)

0.12

Hb d0

median [range]

9.7

[6.0–12.7]

9.7

[5.0–11.7]

9.7

[6.7–12.7]

9.7

[6.7–12.7]

 

10.7

[6.7–12.7]

10.7

[6.7–14.0]

10.7

[6.0–14.0]

 

Anaemia* d0 (%)

100

(93.4)

102

(96.2)

83

(91.2)

83

(92.2)

0.51

31

(51.7)

39

(62.9)

36

(62.1)

0.38

Hb d28

median [range]

10.7

[6.7–12.7]

10.7

[6.7–12.7]

10.7

[7.0–12.7]

10.7

[7.3–12.7]

 

11.7

[10.7–12.7]

11.7

[9.7–12.7]

11.7

[9.7–14.0]

 
  1. * Defined by haemoglobin below 11 g/dL
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Malaria Journal

ISSN: 1475-2875

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