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Table 2 Laboratory monitoring of biological events of ANQ and CQ+SP treatments

From: Artemisinin-naphthoquine combination (ARCO™) therapy for uncomplicated falciparum malaria in adults of Papua New Guinea: A preliminary report on safety and efficacy

Laboratory parameters Treatments D0 D3 D7 D14 21 28
Biochemistry        
Glucose
mm/L
ANQ 4.9 ± 0.9 5.5 ± 1.5 4.8 ± 0.8 4.5 ± 0.8 4.5 ± 0.5 5.0 ± 1.6
  CQ+SP 5.0 ± 1.0 5.5 ± 1.5 4.9 ± 0.8 4.5 ± 0.8 4.6 ± 0.5 5.2 ± 1.6
Liver function        
*AST
Units/L
ANQ 43.2 ± 16.4 43.7 ± 22.6 41.6 ± 32.1 35.7 ± 17.9 31.0 ± 10.4 33.4 ± 10.2
  CQ+SP 44.2 ± 16.4 43.2 ± 16.4 42.2 ± 32.1 35.2 ± 17.9 31.0 ± 10.4 35.4 ± 10.2
**ALT
Units/L
ANQ 44.1 ± 20.9 47.9 ± 24.9 53.0 ± 49.2 57.3 ± 33.7 36.4 ± 14.8 36.3 ± 21.4
  CQ+SP 46.1 ± 20.9 47.9 ± 24.9 54.0 ± 49.2 57.3 ± 34.0 36.4 ± 14.9 35.3 ± 21.4
Bilirubin
μm/L
ANQ 19.4 ± 14.3 12.1 ± 8.8 10.7 ± 5.0 8.3 ± 1.5 8.8 ± 1.3 8.8 ± 1.9
  CQ+SP 18.4 ± 14.3 12.1 ± 8.8 10.6 ± 5.0 8.3 ± 1.5 8.0 ± 1.3 8.8 ± 2.0
Alkaline phosphatase
Units/L
ANQ 75.9 ± 18.6 81.8 ± 24.7 87.5 ± 27.5 91.3 ± 29.5 80.5 ± 24.3 95.1 ± 38.1
  CQ+SP 76.4 ± 20.2 83.4 ± 23.1 86.1 ± 25.2 91.8 ± 28.4 77.6 ± 21.5 84.0 ± 39.0
#GGT
Units/L
ANQ 39.5 ± 22.7 40.3 ± 24.8 34.7 ± 22.3 29.5 ± 13.5 16.8 ± 11.9 22.5 ± 7.4
  CQ+SP 40.5 ± 22.7 40.3 ± 24.8 34.7 ± 22.3 29.5 ± 13.5 16.3 ± 12.9 22.5 ± 7.5
Renal function        
Creatinine
μm/L
ANQ 92.7 ± 19.4 91.8 ± 14.2 91.9 ± 18.1 87.9 ± 13.7 85.9 ± 10.9 79.3 ± 17.5
  CQ+SP 93.3 ± 19.3 92.8 ± 14.4 93.5 ± 19.1 88.9 ± 14.0 85.3 ± 11.5 80.4 ± 18.4
Haematology        
Haemoglobin
g/dl
ANQ 10.8 ± 2.3 10.6 ± 1.8 10.4 ± 1.2 10.7 ± 1.0 11.1 ± 1.7 11.6 ± 1.4
  CQ+SP 11.0 ± 2.3 10.7 ± 1.9 10.5 ± 1.3 11.0 ± 0.9 11.1 ± 1.6 11.6 ± 1.5
WBC
×109/L
ANQ 5.2 ± 2.4 5.4 ± 1.7 5.5 ± 1.7 6.5 ± 2.5 6.6 ± 1.6 6.1 ± 1.7
  CQ+SP 5.4 ± 2.3 5.4 ± 1.6 5.8 ± 1.6 6.5 ± 2.3 6.6 ± 1.7 6.2 ± 1.8
Electrolytes        
Sodium
mm/L
ANQ 134.9 ± 5.6 138.2 ± 3.4 135.6 ± 7.6 137.2 ± 2.6 136.5 ± 3.1 139.6 ± 5.4
  CQ+SP 135.9 ± 5.5 138.3 ± 3.3 136.1 ± 7.1 137.2 ± 2.4 136.4 ± 2.9 140.0 ± 5.5
Potassium
mm/L
ANQ 3.8 ± 0.7 4.1 ± 1.1 4.2 ± 0.8 4.1 ± 0.7 3.9 ± 0.3 4.0 ± 0.7
  CQ+SP 3.8 ± 0.7 4.1 ± 0.7 4.2 ± 0.7 4.0 ± 0.7 4.0 ± 0.7 4.1 ± 1.0
  1. *AST = Aspartate aminotransferase ** ALT = Alanine aminotransferase #GGT = Gamma-glutamyltransferase