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Table 3 Estimated pharmacokinetic parameters for desethylamodiaquine

From: Population pharmacokinetics of artesunate and amodiaquine in African children

Parameter

Estimate (SE)

Inter-subject variation CV%

Ka (h-1)

0.13 (fixed)

 

CL/F (L kg-1 h-1)

0.610 (0.038)

22.7%

Q (L kg-1 h-1)

0.680 (0.306)

 

Vcentral/F (L kg-1)

35.4 (11.5)

 

Vperipheral/F (L kg-1)

87.9 (17.1)

 

T 1/2 (days)

9.0 [7.3–11.6]1

 

σ

0.457

 
  1. 1range of predicted values;
  2. Ka – absorption rate constant; CL/F – total clearance;
  3. Q – inter-compartmental clearance; Vcentral/F – volume of the central compartment;
  4. Vperipheral/F – volume of the peripheral compartment; F – fraction of drug absorbed;
  5. σ – residual additive error on the loge scale.
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Malaria Journal

ISSN: 1475-2875

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