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Table 4 Estimated dihydroartemisinin and total anti-malarial activity pharmacokinetic parameters.

From: Population pharmacokinetics of artesunate and amodiaquine in African children

Parameter

Estimate (SE)

Inter-subject variation CV%

DHA

  

Ka (h -1)

4.271 (2.091)

 

CL/F1 (L kg-1 h-1)

0.636 (0.075)

 

Increase in CL/F due to the 3rd dose period

0.760 (0.160)

 

V/F (L kg-1)

2.285 (0.317)

47%

Effect of Age on V/F

0.063 (0.015)

 

T 1/2 (h)

  

   1st dose

2.5 [0.8–4.5]2

 

   3rd dose

1.1 [0.4–2.0]2

 

σ (ng/mL)

340

 

Anti-malarial Activity

  

Ka (h-1)

4.744 (2.587)

 

CL/F1 (L kg-1 h-1)

0.616 (0.071)

 

Increase in CL/F due to the 3rd dose period

0.662 (0.150)

 

V/F (L kg-1)

2.134 (0.287)

48%

Effect of Age on V/F

0.063 (0.013)

 

T 1/2 (h)

  

   1st dose

2.4 [0.5–5.7]2

 

   3rd dose

1.2 [0.2–2.7]2

 

σ (ng/mL)

353

 
  1. 1population mean estimate of CL/F for the first dose period
  2. 290% range of predicted values;
  3. Ka – absorption rate constant; CL/F – total clearance; V/F – volume of distribution; F – fraction of drug absorbed; σ – residual additive error in DHA units