Overall risks of failure of artesunate-amodiaquine by comparator: (A) crude, (B) PCR-adjusted Day 28 outcome. Note: The forest plot represents the risk of failure of artesunate amodiaquine versus comparators in randomized comparative studies. Results were stratified by site. The size of boxes is proportional to the number of patients included. The square represents the adjusted hazard ratio and 95% CI.