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Table 4 AS&AQ groups: crude and PCR-adjusted Day 28 efficacy results presented by site and country

From: Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis

Efficacy by Day 28 by country and site * Number of patients enrolled receiving ASAQ Crude (not adjusted for reinfection) PCR-adjusted
   Efficacy Lower 95% confidence interval Upper 95% confidence interval Efficacy Lower 95% confidence interval Upper 95% confidence interval
Angola (all) 166 92.0% 83.0% 96.3% 98.6% 90.5% 99.8%
   Angola-Caala 69 91.0% 81.1% 95.9% 98.4% 89.3% 99.8%
   Angola-Kuito 97 92.9% 84.9% 96.8% 98.8% 91.7% 99.8%
Burkina Faso (all) 923 96.7% 91.4% 97.5% NA NA NA
   Burkina Faso-Bobo-Dilaossou 33 100% 91.3% 100.0% NA NA NA
   Burkina Faso-Pouytenga 890 93.5% 91.5% 95.0% 97.3% 95.9% 98.2%
Cameroun-Mendong 110 98.1% 92.5% 99.5% 100.0% 100.0% 100.0%
Congo-Kindamba# 101 67.5% 57.0% 75.9% 84.2% 74.8% 90.4%
Gabon-Lambarene 110 87.5% 79.1% 92.7% 94.5% 87.3% 97.7%
Guinea-Dabola 110 94.4% 87.9% 97.4% 99.1% 93.6% 99.9%
Kenya-Migori# 200 76.5% 69.1% 82.4% 89.5% 83.4% 93.5%
Madagascar-Tsiroanomandidy 119 96.6% 91.2% 98.7% 99.2% 94.1% 99.9%
Mali (all) 387 74.5% 67.4% 80.4% 98.3% 94.6% 99.5%
   Mali-Bancoumana 135 68.5% 59.7% 75.7% 97.5% 92.3% 99.2%
   Mali-Bougoula 252 80.6% 75.1% 85.0% 99.2% 96.8% 99.8%
DRC (all) 136 74.5% 62.5% 82.0% 88.3% 76.6% 93.1%
   DRC-Boende# 90 57.7% 46.5% 67.4% 78.7% 67.6% 86.4%
   DRC-Kabalo 46 91.3% 78.5% 96.6% 97.8% 85.6% 99.7%
Rwanda (all) 410 82.4% 75.1% 87.5% 91.6% 85.6% 95.0%
   Rwanda-Kicukiro 122 91.6% 85.0% 95.4% 95.8% 90.2% 98.2%
   Rwanda-Mashesha 150 86.7% 80.1% 91.2% 95.3% 90.3% 97.7%
   Rwanda-Rukara# 138 68.8% 60.2% 75.9% 83.8% 76.1% 89.1%
Sénégal (all) 1390 96.1% 91.4% 98.5% NA NA NA
   Senegal-Keur Socé 264 94.2% 90.9% 96.7% 99.2% 96.8% 99.8%
   Senegal-Djembeye 110 95.3% 91.3% 99.3% NA NA NA
   Senegal-Kabrousse 27 100% 89.1% 100.0% NA NA NA
   Senegal-Mlomp 883 95.8% 94.4% 97.2% NA NA NA
   Senegal-Oussouye 106 95.3% 91.3% 99.3% NA NA NA
Sierra-Leone-kailahun# 126 40.5% 31.5% 49.4% 87.5% 78.5% 92.9%
Sudan (all) 214 76.1% 66.8% 83.1% 88.4% 79.8% 93.4%
   South Sudan-Nuba# 80 63.8% 52.2% 73.2% 84.9% 74.4% 91.4%
   Sudan-Malakal 134 88.5% 81.3% 93.0% 91.8% 85.3% 95.5%
Uganda (all) 1283 53.3% 46.5% 59.6% 91.1% 85.1% 94.7%
   Uganda-Amudat# 106 30.3% 21.3% 39.9% 89.9% 79.2% 95.2%
   Uganda-Apac# 174 46.5% 38.9% 53.8% 87.2% 80.6% 91.7%
   Uganda-Arua# 174 49.3% 41.7% 56.6% 88.8% 82.5% 92.9%
   Uganda-Jinja 189 79.5% 72.9% 84.6% 94.3% 89.6% 96.9%
   Uganda-Kampala 242 83.8% 78.4% 87.9% 95.7% 92.1% 97.7%
   Uganda-Tororo 398 30.2% 25.7% 34.8% 91.1% 86.8% 94.0%
Zanzibar (all) 202 75.6% 64.9% 83.3% 91.8% 83.1% 96.2%
   Zanzibar-Kivunge 148 73.5% 65.5% 79.9% 95.0% 89.7% 97.6%
   Zanzibar-Micheweni# 54 77.8% 64.2% 86.7% 88.7% 76.5% 94.7%
  1. *Mean efficacies are given for countries with multiple sites
  2. # Efficacy PCR adjusted <90%
  3. NA: not applicable, no PCR genotyping data for all sites from that country