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Table 4 Summary of the Day-42 ACPR rates and difference (95% confidence intervals), the data is not PCR corrected

From: Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi

Day-42 Outcome

ACPR Rate

ACPR Difference (95% Confidence Intervals)

P value

ITT (missing = failure)

CPD (n = 166)

55.4%

  

AL (n = 82)

75.6%

  

SP (n = 82)

46.3%

  

CPD vs SP

 

9.1%

(-4.1%, 22.3%)

0.224

AL vs CPD

 

20.2%

(8.2%, 32.2%)

0.002

AL vs SP

 

29.3%

(15.0%, 43.5%)

< 0.001

ITT (missing = success)

CPD (n = 166)

72.9%

  

AL (n = 82)

96.3%

  

SP (n = 82)

69.5%

  

CPD vs SP

 

3.4%

(-8.7%, 15.4%)

0.653

AL vs CPD

 

23.4%

(15.6%, 31.3%)

< 0.001

AL vs SP

 

26.8%

(16.1%, 37.6%)

< 0.001

Per Protocol

CPD (n = 137)

75.6%

  

AL (n = 65)

98.3%

  

SP (n = 63)

62.5%

  

CPD vs SP

 

6.8%

(-7.6%, 21.3%)

0.425

AL vs CPD

 

28.2%

(18.9%, 37.6%)

< 0.001

AL vs SP

 

35.1%

(22.0%, 48.2%%)

< 0.001