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Table 3 Proportion of children with worse performance on day 7 and day 28 compared to day 0, after treatment with AS7 or MAS7 for P. falciparum, and in the non febrile controls.

From: The neurological assessment in young children treated with artesunate monotherapy or artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria

   Day 7 - Day 0  
Neurological Test Component Result compared to previous test AS7 N = 39 MAS7 N = 39 Controls non febrile N = 35 P* 2 × 2 a 2 × 2 b
Box Worse 11.6 (5) 16.3 (7) 11.4 (4) 0.757 0.455
Cube Worse 14.0 (6) 16.3 (7) 31.4 (11) 1.000 0.186
Ring Worse 11.6 (5) 11.6 (5) 11.4 (4) 1.000 0.285
Coin Worse 4.7 (2) 2.3 (1) 2.9 (1) 1.000 0.178
Behaviour Worse 11.6 (5) 14.0 (6) 31.4 (11) 1.000 < 0.001
Tone Decreased 41.9 (18) 40.5 (17) 8.8 (3) 1.000 0.026
   Day 28 - Day 0  
Box Worse 5.1 (2) 7.7 (3) 9.7 (3) 1.000 0.686
Cube Worse 15.4 (6) 20.8 (8) 16.1 (5) 0.769 1.000
Ring Worse 5.1 (2) 7.7 (3) 25.8 (8) 1.000 0.009
Coin Worse 5.1 (2) 5.1 (2) 9.7 (3) 1.000 0.403
Behaviour Worse 15.4 (6) 10.3 (4) 45.2 (14) 0.737 0.001
Tone Decreased 51.3 (20) 44.7 (17) 19.4 (6) 0.650 0.009
  1. *P value comparison of proportions a of 2 × 2 for AS7 vs MAS7, b 2 × 2 tables for malaria treatment pooled vs controls