Table 1 IC50s for OZ277, AS, CQ, PYR and MEF obtained from the aldolase ELISA and the [3H]hypoxanthine method with the P. falciparum strain NF54
Anti-malarial compound | Drug assay (n = 3) | IC 50 ± SD (ng/ml) | [3H]hypoxanthine data (ng/ml) from Vennerstrom et al, 2004; Maerki et al, 2006 |
|---|---|---|---|
OZ277 | [3H]hypoxanthine | 0.36 (± 0.03) | 0.91 (± 0.12) |
OZ277 | Aldolase ELISA | 0.63 (± 0.18) |  |
AS | [3H]hypoxanthine | 0.91(± 0.32) | 1.6 (± 0.1) |
AS | Aldolase ELISA | 1.6 (± 0.3) |  |
CQ | [3H]hypoxanthine | 3.8 (± 0.5) | 5.1 (± 0.8) |
CQ | Aldolase ELISA | 5.3 (± 0.7) |  |
PYR | [3H]hypoxanthine | 3.8 (± 0.6) | 5.6 (± 0.5) |
PYR | Aldolase ELISA | 7.9 (± 2.1) |  |
MEF | [3H]hypoxanthine | 4.3 (± 1.0) | 5.8 (± 0.2) |
MEF | Aldolase ELISA | 6.9 (± 0.5) |  |