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Table 1 IC50s for OZ277, AS, CQ, PYR and MEF obtained from the aldolase ELISA and the [3H]hypoxanthine method with the P. falciparum strain NF54

From: A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity

Anti-malarial compound Drug assay (n = 3) IC 50 ± SD (ng/ml) [3H]hypoxanthine data (ng/ml) from Vennerstrom et al, 2004; Maerki et al, 2006
OZ277 [3H]hypoxanthine 0.36 (± 0.03) 0.91 (± 0.12)
OZ277 Aldolase ELISA 0.63 (± 0.18)  
AS [3H]hypoxanthine 0.91(± 0.32) 1.6 (± 0.1)
AS Aldolase ELISA 1.6 (± 0.3)  
CQ [3H]hypoxanthine 3.8 (± 0.5) 5.1 (± 0.8)
CQ Aldolase ELISA 5.3 (± 0.7)  
PYR [3H]hypoxanthine 3.8 (± 0.6) 5.6 (± 0.5)
PYR Aldolase ELISA 7.9 (± 2.1)  
MEF [3H]hypoxanthine 4.3 (± 1.0) 5.8 (± 0.2)
MEF Aldolase ELISA 6.9 (± 0.5)  
  1. Geometric mean IC50s with 95% CIs for OZ277, artesunate (AS), chloroquine (CQ), pyrimethamine (PYR) and mefloquine (MEF) determined side-by-side by [3H]hypoxanthine assay and aldolase ELISA. Previously published IC50s for [3H]hypoxanthine assay are given for comparison. Mean values shown from n = 3 independent experiments.