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Table 4 Evaluation of in vitro inhibition of sporozoite invasion (ISI) by rabbit antibodies against different regions of MB2

From: Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals

IgG

SPOROZOITES/WELL

MEAN ± SDa

% INHIBITIONb

MB2-B

   

PRE-IMMUNE

522, 514, 593

543 ± 35

0

MB2-B

205, 251, 238

231 ± 19

57%

MB2-C c

   

PRE-IMMUNE

216, 312, 240

256 ± 40

0

MB2-C

252, 177, 198

209 ± 31

18%

MB2-FA c

   

PRE-IMMUNE

472, 485, 438

465 ± 20

0

MB2-FA

263, 354, 306

307 ± 37

33%

mAb NFS1

11, 9, 6

8 ± 2

97%

MEMdControl

280, 350, 325

318 ± 29

0

  1. a SD, standard deviation
  2. b Inhibition expressed as % relative to pre-immune control culture (0%), and it was calculated as follows: 100 × [1 - (mean number of invaded sporozoites in test culture/mean number of invaded sporozoites in control culture)]. Pre-immune antibodies used as negative control.
  3. c These peptides contain amino acid repeat motifs.
  4. dMEM Minimal essential medium.