Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

Table 10 Summary table of test performance

	CareStart™ Malaria 2 line pLDH (Pan)	CareStart™ Malaria three line pLDH (Pan, PF)	OptiMAL-IT^®
PF detection ¹ sensitivity % [CI ⁹⁵ ]	95.6 [87.7-98.5]	94.7 [88.9-97.5]	94.7 [88.9697.5]
PV detection ¹ sensitivity % [CI ⁹⁵ ]	91 [86.5-94.1]	80.6 [74.9-85.3]	91.8 [87.4-94.8]
Heat stable at 90 days at 35°C	Yes	Yes	No
Ease of Use Ranking	1	1	3
Time to negative, days	2	2	7
Inter-reader agreement	Excellent	Excellent	Excellent
Cost (USD)	0.6	1	1.5
Invalid tests %	1	1.6	0.8

¹Compared to microscopy with presence of gametocytes regarded as a NEGATIVE result for that species

ISSN: 1475-2875