Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

Table 3 Sensitivity, specificity, positive and negative predictive values of CareStart™ Malaria 2 line pLDH (Pan) results compared to microscopy results

	Sensitivity	Specificity	Positive Predictive Value	Negative Predictive Value
PF/other ¹ (PF gametocytaemia considered negative for PF)	89.1 [85.5-91.8]	97.6 [96.5-98.4]	93.8 [90.8-95.9]	95.2 [94.2-96.8]
PF/other ² (PF gametocytaemia considered positive for PF)	85.1 [81.3-88.2]	96.1 [94.7-97.2]	90.6 [87.3-93.2]	93.6 [91.9-95.0]
PF mono-infection ¹ (PF gametocytaemia considered negative for PF)	95.6 [87.7-98.5]	-	-	-
PF mono-infection ² (PF gametocytaemia considered positive for PF)	86.7 [79.9-91.4]	-	-	-
PV mono-infection ¹ (PV gametocytaemia considered negative for PV)	91.0 [86.5-94.1]	-	-	-
PV mono-infection ² (PV gametocytaemia considered positive for PV)	88.4 [83.7-91.9]	-	-	-

Note
1329 CareStart™ Malaria 2 line pLDH (Pan) tests performed; 13 (1%) were invalid, results were missing for 1 (0.1%) test., thus results of 1315 tests were evaluated.
Results expressed as % with 95% confidence intervals in brackets
Specificity not calculated for monoinfections since false positives for species individually cannot be estimated.
¹ Solitary gametocytaemia considered as a negative result for that species
²Solitary gametocytaemia considered as a positive result for that species

ISSN: 1475-2875