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Table 3 Sensitivity, specificity, positive and negative predictive values of CareStart™ Malaria 2 line pLDH (Pan) results compared to microscopy results

From: Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

  Sensitivity Specificity Positive Predictive Value Negative Predictive Value
PF/other 1 (PF gametocytaemia considered negative for PF) 89.1 [85.5-91.8] 97.6 [96.5-98.4] 93.8 [90.8-95.9] 95.2 [94.2-96.8]
PF/other 2 (PF gametocytaemia considered positive for PF) 85.1 [81.3-88.2] 96.1 [94.7-97.2] 90.6 [87.3-93.2] 93.6 [91.9-95.0]
PF mono-infection 1 (PF gametocytaemia considered negative for PF) 95.6 [87.7-98.5] - - -
PF mono-infection 2 (PF gametocytaemia considered positive for PF) 86.7 [79.9-91.4] - - -
PV mono-infection 1 (PV gametocytaemia considered negative for PV) 91.0 [86.5-94.1] - - -
PV mono-infection 2 (PV gametocytaemia considered positive for PV) 88.4 [83.7-91.9] - - -
  1. Note
  2. 1329 CareStart™ Malaria 2 line pLDH (Pan) tests performed; 13 (1%) were invalid, results were missing for 1 (0.1%) test., thus results of 1315 tests were evaluated.
  3. Results expressed as % with 95% confidence intervals in brackets
  4. Specificity not calculated for monoinfections since false positives for species individually cannot be estimated.
  5. 1 Solitary gametocytaemia considered as a negative result for that species
  6. 2Solitary gametocytaemia considered as a positive result for that species