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Table 3 Sensitivity, specificity, positive and negative predictive values of CareStart™ Malaria 2 line pLDH (Pan) results compared to microscopy results

From: Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

  Sensitivity Specificity Positive Predictive Value Negative Predictive Value
PF/other 1
(PF gametocytaemia considered negative for PF)
89.1
[85.5-91.8]
97.6
[96.5-98.4]
93.8
[90.8-95.9]
95.2
[94.2-96.8]
PF/other 2
(PF gametocytaemia considered positive for PF)
85.1
[81.3-88.2]
96.1
[94.7-97.2]
90.6
[87.3-93.2]
93.6
[91.9-95.0]
PF mono-infection 1
(PF gametocytaemia considered negative for PF)
95.6
[87.7-98.5]
- - -
PF mono-infection 2
(PF gametocytaemia considered positive for PF)
86.7
[79.9-91.4]
- - -
PV mono-infection 1
(PV gametocytaemia considered negative for PV)
91.0
[86.5-94.1]
- - -
PV mono-infection 2
(PV gametocytaemia considered positive for PV)
88.4
[83.7-91.9]
- - -
  1. Note
  2. 1329 CareStart™ Malaria 2 line pLDH (Pan) tests performed; 13 (1%) were invalid, results were missing for 1 (0.1%) test., thus results of 1315 tests were evaluated.
  3. Results expressed as % with 95% confidence intervals in brackets
  4. Specificity not calculated for monoinfections since false positives for species individually cannot be estimated.
  5. 1 Solitary gametocytaemia considered as a negative result for that species
  6. 2Solitary gametocytaemia considered as a positive result for that species