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Table 4 Sensitivity, specificity, positive and negative predictive values of CareStart™ Malaria 3 line pLDH (Pan, Pf) and OptiMAL-IT® results compared to microscopy

From: Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

  CareStart™ Malaria pLDH (Pan, PF) OptiMAL-IT®
Sensitivity Specificity Positive Predictive Value Negative Predictive Value Sensitivity Specificity Positive Predictive Value Negative Predictive Value
Pf +/- other 1 93.5
[87.8-96.7]
97.4
[96.3-98.2]
78.9
[71.6-84.7]
99.3
[98.7-99.7]
95.2
[89.8-97.9]
94.7
[93.3-95.8]
65.2
[58.0-71.8]
99.5
[98.9-99.8]
Pf +/- other 2 89.1
[82.8-93.3]
98
[97-98.6]
83.7
[76.9-88.8]
98.7
[97.9-99.2]
91.8
[85.9-95.4]
95.4
[94.1-96.5]
69.5
[62.4-75.8]
99
[98.3-99.5]
Non-Pf 1 78.5
[73-83.1]
97.8
[96.8-98.6]
89.5
[84.8-92.9]
95.1
[93.6-96.2]
90
[85.7-93.1]
96.5
[95.3-97.5]
85.9
[81.1-89.6]
97.6
[96.5-98.4]
Non-Pf 2 77
[71.5-81.8]
97.9
[96.9-98.6]
90
[85.3-95.3]
94.6
[93.1-95.8]
90.2
[86-93.3]
97.1
[95.9-97.9]
88.2
[83.7-91.5]
97.6
[96.5-98.4]
Pf mono-infection 1 94.7
[88.9-97.5]
- - - 94.7
[88.9-97.5]
- - -
Pf mono-infection 2 90.5
[84.1-94.5]
- - - 92.1
[86-95.6]
- - -
Pv mono-infection 1 80.6
[74.9-85.3]
- - - 91.8
[87.4-94.8]
- - -
Pv mono-infection 2 78.9
[73.2-83.7]
- - - 92.1
[87.8-94.9]
- - -
  1. Note
  2. 1337 CareStart™ Malaria 3 line pLDH (Pan, PF) tests performed; 21 (1.6%) were invalid, results were missing for 4 (0.3%) tests, thus results of 1312 tests were evaluated.
  3. 1328 OptiMAL-IT® tests performed; 10 (0.8%) were invalid, results were missing for 1 (0.1%) test, thus results of 1317 tests were evaluated.
  4. Results expressed as % with 95% confidence intervals in brackets
  5. Specificity not calculated since false positives for species individually cannot be estimated.
  6. 1 Solitary gametocytaemia considered as a negative result for that species
  7. 2Solitary gametocytaemia considered as a positive result for that species