Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

Table 4 Sensitivity, specificity, positive and negative predictive values of CareStart™ Malaria 3 line pLDH (Pan, Pf) and OptiMAL-IT^® results compared to microscopy

	CareStart™ Malaria pLDH (Pan, PF)				OptiMAL-IT^®
	Sensitivity	Specificity	Positive Predictive Value	Negative Predictive Value	Sensitivity	Specificity	Positive Predictive Value	Negative Predictive Value
Pf +/- other ¹	93.5 [87.8-96.7]	97.4 [96.3-98.2]	78.9 [71.6-84.7]	99.3 [98.7-99.7]	95.2 [89.8-97.9]	94.7 [93.3-95.8]	65.2 [58.0-71.8]	99.5 [98.9-99.8]
Pf +/- other ²	89.1 [82.8-93.3]	98 [97-98.6]	83.7 [76.9-88.8]	98.7 [97.9-99.2]	91.8 [85.9-95.4]	95.4 [94.1-96.5]	69.5 [62.4-75.8]	99 [98.3-99.5]
Non-Pf ¹	78.5 [73-83.1]	97.8 [96.8-98.6]	89.5 [84.8-92.9]	95.1 [93.6-96.2]	90 [85.7-93.1]	96.5 [95.3-97.5]	85.9 [81.1-89.6]	97.6 [96.5-98.4]
Non-Pf ²	77 [71.5-81.8]	97.9 [96.9-98.6]	90 [85.3-95.3]	94.6 [93.1-95.8]	90.2 [86-93.3]	97.1 [95.9-97.9]	88.2 [83.7-91.5]	97.6 [96.5-98.4]
Pf mono-infection ¹	94.7 [88.9-97.5]	-	-	-	94.7 [88.9-97.5]	-	-	-
Pf mono-infection ²	90.5 [84.1-94.5]	-	-	-	92.1 [86-95.6]	-	-	-
Pv mono-infection ¹	80.6 [74.9-85.3]	-	-	-	91.8 [87.4-94.8]	-	-	-
Pv mono-infection ²	78.9 [73.2-83.7]	-	-	-	92.1 [87.8-94.9]	-	-	-

Note
1337 CareStart™ Malaria 3 line pLDH (Pan, PF) tests performed; 21 (1.6%) were invalid, results were missing for 4 (0.3%) tests, thus results of 1312 tests were evaluated.
1328 OptiMAL-IT^® tests performed; 10 (0.8%) were invalid, results were missing for 1 (0.1%) test, thus results of 1317 tests were evaluated.
Results expressed as % with 95% confidence intervals in brackets
Specificity not calculated since false positives for species individually cannot be estimated.
¹ Solitary gametocytaemia considered as a negative result for that species
²Solitary gametocytaemia considered as a positive result for that species

ISSN: 1475-2875