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Table 4 Sensitivity, specificity, positive and negative predictive values of CareStart™ Malaria 3 line pLDH (Pan, Pf) and OptiMAL-IT® results compared to microscopy

From: Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

  CareStart™ Malaria pLDH (Pan, PF) OptiMAL-IT®
Sensitivity Specificity Positive Predictive Value Negative Predictive Value Sensitivity Specificity Positive Predictive Value Negative Predictive Value
Pf +/- other 1 93.5 [87.8-96.7] 97.4 [96.3-98.2] 78.9 [71.6-84.7] 99.3 [98.7-99.7] 95.2 [89.8-97.9] 94.7 [93.3-95.8] 65.2 [58.0-71.8] 99.5 [98.9-99.8]
Pf +/- other 2 89.1 [82.8-93.3] 98 [97-98.6] 83.7 [76.9-88.8] 98.7 [97.9-99.2] 91.8 [85.9-95.4] 95.4 [94.1-96.5] 69.5 [62.4-75.8] 99 [98.3-99.5]
Non-Pf 1 78.5 [73-83.1] 97.8 [96.8-98.6] 89.5 [84.8-92.9] 95.1 [93.6-96.2] 90 [85.7-93.1] 96.5 [95.3-97.5] 85.9 [81.1-89.6] 97.6 [96.5-98.4]
Non-Pf 2 77 [71.5-81.8] 97.9 [96.9-98.6] 90 [85.3-95.3] 94.6 [93.1-95.8] 90.2 [86-93.3] 97.1 [95.9-97.9] 88.2 [83.7-91.5] 97.6 [96.5-98.4]
Pf mono-infection 1 94.7 [88.9-97.5] - - - 94.7 [88.9-97.5] - - -
Pf mono-infection 2 90.5 [84.1-94.5] - - - 92.1 [86-95.6] - - -
Pv mono-infection 1 80.6 [74.9-85.3] - - - 91.8 [87.4-94.8] - - -
Pv mono-infection 2 78.9 [73.2-83.7] - - - 92.1 [87.8-94.9] - - -
  1. Note
  2. 1337 CareStart™ Malaria 3 line pLDH (Pan, PF) tests performed; 21 (1.6%) were invalid, results were missing for 4 (0.3%) tests, thus results of 1312 tests were evaluated.
  3. 1328 OptiMAL-IT® tests performed; 10 (0.8%) were invalid, results were missing for 1 (0.1%) test, thus results of 1317 tests were evaluated.
  4. Results expressed as % with 95% confidence intervals in brackets
  5. Specificity not calculated since false positives for species individually cannot be estimated.
  6. 1 Solitary gametocytaemia considered as a negative result for that species
  7. 2Solitary gametocytaemia considered as a positive result for that species