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Table 1 The influence of parasitological status on the association between the risk of clinical episode of malaria and antibodies against various malaria antigens

From: What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity

Study population [ref]

Antigen

Parasites alone

Antibodies alone

Parasites + Antibodies

Chonyi [50]

AMA1 Pro/DI/II/III

2.65 (P < 0.050)

1.87 (P = 0.093)

0.38 (P < 0.050)

Chonyi [50]

AMA1 DI/II/III

 

2.12 (P = 0.049)

0.049 (P < 0.050)

Chonyi [7]

MSP2 type A

2.95 (P < 0.050)

8.94 (P = 0.008)

0.47 (P = 0.414)

Chonyi[7]

MSP2 type B

3.97 (P < 0.050)

0.76 (P = 0.599)

0.83 (P = 0.818)

chonyi [51]

MSP3

 

1.14 (P = 0.717)

0.41 (P = 0.011)

Ngerenya[52]

VSA (isolate A4U)

3.78 (P = 0.022)

1.35 (P= 0.567)

1.67 (P = 0.325)

 

VSA (isolate A4 40C)

5.35 (P = 0.005)

2.88 (P = 0.064)

1.55 (P = 0.402)

 

VSA (isolate 3D7)

7.10 (P = 0.004)

2.01 (P = 1.700)

1.43 (P= 0.479)

 

VSA (isolate P1)

2.53 (P = 0.035)

3.72 (P = 0.050)

1.38 (P = 0.587)

Antibody responses stratified by titre

 

Variant surface antigens

Ngerenya [18]

Medium tertile

5.90 (P = 0.018)

2.05 (P = 0.06)

0.21 (P = 0.200)

 

Highest tertile

 

4.34 (P = 0.01)

0.09 (P = 0.041)

 

MSP2 type A

Chonyi [7]

Lowest quartile

2.95 (P < 0.050)

 

4.27 (P = 0.050)

 

Highest quartile

  

0.56 (P = 0.418)

Ngerenya [7]

Lowest quartile

1.66 (P < 0.050)

 

1.11 (P = 0.740)

 

Highest quartile

  

0.39 (P = 0.044)

 

MSP2 type b

Chonyi [7]

Lowest quartile

3.97 (P < 0.050)

 

1.31 (P = 0.530)

 

Highest quartile

  

0.19 (P = 0.013)

Ngerenya [7]

Lowest quartile

1.58 (P < 0.050)

 

1.37 (P = 0.547)

 

Highest quartile

  

0.78 (P = 0.560)

  1. Age adjusted risk of suffering a clinical episode of malaria among children in two areas of Kilifi, Kenya (Ngerenya - low transmission and Chonyi- moderate transmission) during follow-up depending on their anti-malarial antibody serological and malaria parasitological status at pre-follow-up cross-section survey. Significant associations (P < 0.05) are highlighted in bold. AMA 1 (Pro/DI, II, III) -Apical Membrane Antigen 1 prodomain and domains 1, 2, and 3. MSP2/3- Merozoite Surface Protein 2/3, VSA - Variant Surface Antigen.