Skip to main content
Figure 3 | Malaria Journal

Figure 3

From: Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells

Figure 3

TLR-induced cytokine responses in CBMC obtained from women with or without MP accumulation in placenta. CBMC (2 million/ml) were stimulated or not with synthetic Hz (5 μg/ml), LPS (100 ng/ml), CpG-A (3 μg/ml) or PolyI:C (20 μg/ml). After 18 hours, supernatants were collected and analysed for IL-6, IL-10, IL-12, IFN-α, TNF-α and MIP-1α/CCL3 levels. Data represent median values and percentiles for 59 individuals; 16 MP-positive (diagonal striped bars) and 43 MP-negative mothers (white bars). Cytokine levels in unstimulated cells were subtracted from the values shown. P-values were calculated by Mann-Whitney U test or t test (see Subjects, Materials and Methods). The significance limit was P < 0.05.

Back to article page