Skip to main content

Table 3 Immunophenotype of fetal APC upon TLR and Hz stimulation.

From: Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells

    Monocytes    MDC  
Parameter
median (± interquartile)
stimulus Total CB MP-Negative MP-Positive Total CB MP -Negative MP-Positive
% HLA-DR+ cells unstimulated 89.34 ± (13.90) 89.33 ± (16.57) 89.79 ± (7.27) 88.78 ± (19.83) 87.33.40 ± (19.83) 92.62 ± (20.13)
  Hz 91.03 ± (10.10) 90.46 ± (11.97) 92.27 ± (8.31) 90.99 ± (12.22) 89.40 ± (13.55) 91.37 ± (7.88)
  LPS 96.73 ± (6.22) 96.73 ± (7.61) 96.45 ± (3.14) 93.24 ± (11.08) 93.24 ± (11.66) 93.38 ± (15.23)
  Poly I:C 96.79 ± (4.68) 96.79 ± (7.99) 96.70 ± (2.27) 93.99 ± (12.57) 93.08 ± (9.54) 92.09 ± (16.42)
HLA-DR, MFIa unstimulated 120.81 ± (20.14) 121.15 ± (24.36) 119.54 ± (16.48) 143.85 ± (23.19) 143.57 ± (21.28) 149.29 ± (22.77)
  Hz 122.08 ± (20.42) * 125.36 ± (23.00) 121.47 ± (15.15) 146.96 ± (14.93) 151.30 ± (14.69) 156.06 ± (20.47)
  LPS 135.72 ± (16.78)* 137.56 ± (18.02) 133.23 ± (13.82) 152.40 ± (16.28)* 145.49 ± (19.31) 150.67 ± (13.84)
  Poly I:C 136.53 ± (15.66)* 137.27 ± (19.29) 136.41 ± (13.51) 150.16 ± (14.93)* 150.61 ± (16.72) 149.60 ± (16.35)
  1. Immunophenotyping on stimulated cells was performed on 43 cord blood samples (total CB); 12 from women with MP accumulation in placenta (MP-Positive) and 31 without MP in placenta (MP-negative). All comparison between MP-Negative and MP-Positive were not significant.
  2. a; MFI, mean fluorescence intensity
  3. *; P < 0.05