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Table 1 Characteristics of study population according to HIV-1 status

From: The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia

Characteristic

No HIV-1 infection

(n = 224)

HIV-1 infection

(n = 115)

P Value

Mean weight, kg (SD)

56.98

56.89

0.95

Number of women, N (%)

98 (43.8)

72 (62.6)

0.001

Mean age, years (SD)

24.7 (9.1)

29.5 (7.6)

<0.001

Mean white blood cell count, *109/L (SD)†

5.3 (1.9)

5.1 (1.7)

0.26

Mean hemoglobin, g/L (SD)

140 (20)

124 (25)

<0.001

Mean Log Viral load HIV-1 RNA copies/μL (SD)

 

4.87 (0.64)

 

Mean (geometric) parasite density/μL (range)†

9,715 (378-153,120)

9,566 (390-158,894)

0.92

Mean (geometric) CD4 count baseline/μL (95%CI)‡

458 (427-492)

259 (242-277)

<0.001

Mean (geometric) CD4 count day45/μL (95%CI) §

839 (769-915)

379 (317-454)

<0.001

Low responders to Combined merozoite antigens, N(%)

42 (18.8)

35 (30.4)

0.02

Low responders to Combined Variant Surface Antigens¶, N (%)

68 (30.4)

33 (28.7)

0.75

  1. *P value based on Students' t- test, Chi square or Wilcoxon Rank -Sum as required
  2. † Data on WBC were missing in 1 patient in the non-HIV-1 infected group and in 2 in the HIV-1 infected group
  3. ‡ Data on baseline CD4 count were missing in 6 patients in the non-HIV-1 infected group and in 4 in the HIV-1 infected group
  4. §Data on CD4 count on day 45 used only from patients without parasitaemia; non-HIV-1 infected group n = 108, HIV-1 infected group n = 66
  5. //Low responders are <geometric mean for Merozoïte antigens AMA -1, MSP2 3D7 and MSP2 FC27 and Variant Surface Antigens from parasite lines E8B, A4, and HCD6.
  6. ¶After adjustment for CD4 count and age, low responders remained associated with HIV-1 infection (OR:2.40, P = 0.01), parasite load (OR: 1.62, P = 0.06) and absence of anemia (OR:0.55, P = 0.07).