The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia

Table 2 Factors Influencing Antibody Levels to Merozoite Blood Stage Antigen within HIV-1 infected Population (N = 115)

Merozoite Blood Stage Antigen
Risk factor	AMA -1				MSP2 3D7				MSP2 FC27				Low Responders
	Univariate		Multivariate		Univariate		Multivariate		Univariate		Multivariate		Univariate		Multivariate
	Slope	P	Slope	P	Slope	P	Slope	P	Slope	P	Slope	P	OR	P	OR	P
CD4 count day 0 (log ¹⁰ /μL)	0.68	0.03	0.9	0.003	0.04	0.86	-0.02	0.92	0.21	0.38	-	-	0.71	0.19	0.44	0.31
Parasite load (log ¹⁰ /μL)	-0.21	0.13	-	-	-0.22	0.03	-0.25	0.02	-0.19	0.08	-	-	1.59	0.05	-	-
White Blood cell Count *(10 ⁹ /L)**	-0.02	0.63	-0.02	0.58	-0.05	0.14	-	-	-0.03	0.64	-	-	1.03	0.21	1.03	0.82
Hemoglobin day 0 (g/L)	-0.06	0.07	-0.1	0.01	-0.05	0.03	-	-	-0.03	0.33	-	-	1.14	0.83	0.39	0.03
Viral load (log ¹⁰ RNA copies/μL)†	-0.11	0.48	-	-	0.02	0.82	-	-	0.1	0.45	-	-	0.95	0.95	-	-
Age (years)	-0.01	0.53	-	-	0.003	0.74	-	-	0.01	0.43	-	-	1	0.9	-	-
Gender	-0.01	0.96	-	-	0.11	0.4	-	-	0.12	0.4	-	-	1.17	0.7	-	-
Weight (Kg)	-0.003	0.65	-	-	-0.01	0.09	-	-	-0.01	0.02	-	-	1.02	0.12	-	-

Values that reached statistical significance in multivariate analysis are indicated in bold † Viral load was not included in multivariate analyses due to many missing values (35/80)

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