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Table 3 Factors Influencing Antibody Levels to Variant Surface Antigen within HIV-1 infected Population (N = 115)

From: The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia

Variant Surface Antigen

Risk factor

VSA E8B

VSA A4

VSA HCD6

Low responders

 

Univariate

Multivariate

Univariate

Multivariate

Univariate

Multivariate

Univariate

Multivariate

 

Slope

P

Slope

P

Slope

P

Slope

P

Slope

P

Slope

P

OR

P

OR

P

CD4 count day 0 (log 10 /μL)

-0.44

0.19

-

-

-0.41

0.23

-

-

-0.05

0.71

-

-

1.66

0.52

-

-

Parasite load (log 10 /μL)*

-0.29

0.05

-0.72

0.003

-0.3

0.04

-0.72

0.002

-0.11

0.07

-0.24

0.005

1.78

0.12

2.17

0.05

White Blood cell Count

(*10 9 /L)

0.07

0.21

-

-

0.04

0.46

-

-

0.03

0.12

-

-

0.83

0.18

0.78

0.07

Hemoglobin day 0 (g/L)

0.01

0.83

-

-

-0.02

0.65

-

-

0.001

0.97

-

-

0.81

0.62

-

-

Viral load

(log 10 RNA copies/μL)†

0.13

0.49

-

 

-0.05

0.77

-

-

-0.01

0.92

  

0.83

0.62

-

-

Age

(years)

-0.01

0.3

-

-

-0.01

0.14

-

-

-0.01

0.14

-

-

1.03

0.34

-

-

Gender

0.22

0.22

-

-

0.17

0.36

-

-

0.01

0.92

-

-

0.65

0.32

-

-

Weight

(Kg)

-0.01

0.12

-

-

-0.01

0.05

-

-

-0.01

0.06

0.003

0.19

1.02

0.16

-

-

  1. Values that reached statistical significance in multivariate analysis are indicated in bold
  2. * Stratified on white blood cell count (median 4.9), statistical significance only reached in subgroup with white blood cell count _ 4.9 (median)
  3. † Viral load was not included in multivariate analyses due to many missing values (35/80)