Table 1 The panel of modified MSP119 antigens
Amino acid substitutions in the primary sequence | ||
|---|---|---|
Position(s) | Wildtype residue | Variant residue |
Single amino acid | ||
6 | Gln | Ile |
14 | Gln | Arg |
32 | Leu | Arg |
33 | Asn | Ile |
40 | Lys | Ile |
Multiple amino acid s | ||
12+28 | Cys+Cys | Ile+Trp |
34+39 | Tyr+Asp | Ser+Thr |
43+48 | Glu+Thr | Leu+Lys |
15+27+31+43 | Asn+Glu+Leu+Glu | Arg+Tyr+Arg+Leu |
27+31+34+43 | Glu+Leu+Tyr+Glu | Tyr+Arg+Ser+Leu |