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Table 1 Model Parameter Values

From: Cost-effectiveness analysis of rapid diagnostic test, microscopy and syndromic approach in the diagnosis of malaria in Nigeria: implications for scaling-up deployment of ACT

No. Disease Parameter Estimate Source
P1 Malaria prevalence 43.1% Uzochukwu 2008 [42]
P2 Febrile outpatients aged ≥ 5 years   
P3 Proportion of NMFI cases that were bacterial 10% Shillcutt et al. 2008
P4 Probability that a NMFI received an antibiotic 100% Uzochukwu 2008
P5 RDT sensitivity 90% Uzochukwu 2008, Beadle et. al, 1994, Craig et al., 2002, Bell et. al. 2005
P6 Presumptive treatment sensitivity 100% Uzochukwu. 2008
P7 Microscopy sensitivity 82% Uzochukwu. 2008, Shillcutt et. al. 2008, Reyburn et al., 2004
P8 RDT specificity 91% Uzochukwu. 2008, Mueller et al., 2007 Bell et al. 2005, WHO, 2000
P9 Presumptive treatment specificity 0% Uzochukwu. 2008
P10 Microscopy specificity 87% Uzochukwu. 2008
P11 Probability of adherence -- ACT 80% Uzochukwu. 2008, Depoortere et al., 2004, Fogg et al., 2004
P12 Probability of adherence amoxicillin 80% Assumption
P13 ACT efficacy (for malaria) 95% Uzochukwu. 2008. Shillcutt et. al., 2008, Lefevre et. al., 2001
No Disease Parameter Estimate Source
P14 Amoxicillin efficacy (for malaria) 0% Assumption
P15 ACT efficacy (for bacterial infection) 0% Assumption
P16 Amoxicillin efficacy (for bacterial infection) 75% Shillcutt et. al. 2008
P17 ACT efficacy (for viral infection) 0% Assumption
P18 Amoxicillin efficacy (for viral infection) 0% Assumption
  Treatment seeking behaviour   
P19 Outpatient visit at a health centre 1-P20 Shillcutt et.al., 2008
P20 Outpatient visit took place in a hospital 32% Shillcutt et.al., 2008
P21 Patient with severe illness went to hospital for inpatient care after treatment failure 48% Shillcutt et. al., 2008, McCombie, 1996
P22 Patient with uncomplicated illness returned to clinic for outpatient care after treatment failure 48% Shillcutt et.al., 2008
P23 Malaria not effectively treated led to severe disease (age ≥ 5) 1% Shillcutt et. al. 2008
P24 Malaria not effectively treated led to severe disease (age <5) 7.50% Shillcutt et. al. 2008
P25 Bacterial illness not effectively treated led to severe disease (age ≥ 5) 15% Shillcutt et. al. 2008
P26 Bacterial illness not effectively treated led to severe disease (age<5) 30% Shillcutt et. al. 2008
P27 Viral illness not effectively treated led to severe disease (age ≥ 5) 0% Assumption
P28 Viral illness not effectively treated led to severe disease (age<5) 0% Assumption
P29 Severe malaria led to neurological sequelae (age ≥ 5) 1.50% Shillcutt et. al. 2008
P30 Severe malaria led to neurological sequelae (age<5) 3.50% Shillcutt et. al. 2008
P31 Severe bacterial infection led to neurological sequelae (age ≥ 5) 3.80% Shillcutt et. al. 2008
P32 Severe bacterial infection led to neurological sequelae (age<5) 2% Shillcutt et. al. 2008
P33 Inpatient with severe malaria attending an inpatient facility died (all ages) 10% Shillcutt et. al. 2008
P34 Inpatient with severe bacterial illness attending an inpatient facility died (all ages) 15% Shillcutt et. al. 2008
P35 Patient with severe malaria that did not return for formal care would die (all ages) 25% Shillcutt et. al. 2008
P36 Patient with severe bacterial illness that did not return for formal care would die (all ages) P35 Assumption