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Table 1 Clinical Laboratory findings

From: Cardiac complication after experimental human malaria infection: a case report

Haematology and biochemistry tests Reference range Screening Admission Adm +1 Adm +2 Adm +3 Adm +4 = Discharge
Haemoglobin (mmol/l) 7.3 - 9.7 7.1 6.9   7.1   6.9
Leukocytes (*109/l) 3.5 - 11.0 6.6 7.9   3.9   5.4
Platelets (*109/l) 120 - 350 259 160   254   302
Glucose (mmol/l) 4.0 - 5.5 (fasting) 4.6 4.9     
Sodium (mmol/l) 137 - 144 142 140   137   
Potassium (mmol/l) 3.4 - 4.6 4.1 3.9   3.9   
Creatinin (umol/l) 45 - 90 61 55   60   
Urea nitrogen (mmol/l) 3.0 - 7.0   4.9   3.2   
Bilirubin (umol/l) ≤ 17 <10     <10  
Alkaline phosphatase (U/l) ≤ 120 55 74   66 69 69
Aspartate aminotransferase (U/l) ≤ 40 16 132 104 111 89 83
Alanine aminotransferase (U/l) ≤ 45 15 137 134 171 166 164
Lactate dehydrogenase (U/l) ≤ 450 313 540 534 562   384
gamma GT (U/l) ≤ 35 13 29   39 36 35
Creatinin Kinase (U/l) ≤ 170   296 105    28
Troponin I (ug/l) ≤ 0.20   10.40 2.75    0.20
CRP (mg/l) ≤ 10   26     
Cholesterol (mmol/l) 4.7 - 6.5   4.0     
Triglycerides (mmol/l) 0.8 - 2.0   1.5     
HDL cholesterol (mmol/l) 1.10 - 1.70   1.20     
LDL cholesterol (mmol/l) ≤ 3.5   2.12     
Coagulation assays        
INR 0.9-1.1   1.0 1.0    
Fibrinogen (mg/l) 2000-4000    4320    
Factor VIII activity (%) 60-150    130%    
Protein C activity (%) 70-150    >100%    
Free protein S antigen (%) 55-115    92%    
Homocystein (μmol/l) < 13.4    9.3    
Antithrombin III (%) 85-120    98%    
Factor II mutation negative    negative    
Factor V (Leiden) mutation negative    negative    
von Willebrand Factor (%) 50-150   166%     
ADAMTS13 activity (%) 60-140   90%     
Additional tests        
Convalescent microbiological tests adenovirus, RS-virus, influenza virus, mycoplasma pneumonia, Chlamydia, Q-fever, para-influenza, enterovirus Negative
Auto-immune antibodies ANCA, anticardiolipin antibodies, β2 glycoprotein, lupus anticoagulans, anti-heart (rat) antibodies Negative
Toxicology test tetrahydrocannabinol, amphetamine-derivatives, cocaine, diazepam, methadone, tramadol, opiates Negative
Inflammatory parameters Interleukin 6, Interleukin 8 < detection limit
Time after last dose 7 h15 103 h45
Artemether < detection limit < detection limit
Dihydroartemisinin 26.5 ng/ml < detection limit
Lumefantrine 4308 ng/ml and 443 ng/ml
Desbutyl-lumefantrine 40 ng/ml 18 ng/ml