Malaria Journal

Table 5 Chi-square Hardy-Weinberg equilibrium tests for SNP data acquired by DNA microarray technology.

From: A microarray-based system for the simultaneous analysis of single nucleotide polymorphisms in human genes involved in the metabolism of anti-malarial drugs

	Cambodia				Tanzania
	1^st wash		2^nd wash		1^st wash		2^nd wash
SNP	χ ²	P	χ ²	P	χ ²	P	χ ²	P
CYP2A62*	23.00	< 0.01	7.29	< 0.01	23.57	< 0.01	34.02	< 0.01
CYP2B65*	N.A.		N.A.		54.39	< 0.01	32.76	< 0.01
CYP2B66*	N.A.		N.A.		16.90	< 0.01	17.41	< 0.01
CYP2C83*	0.01	0.92	N.A.		8.22	< 0.01	39.35	< 0.01
CYP2C93*	0.01	0.92	N.A.		22.08	< 0.01	11.13	< 0.01
CYP2C95*	0.01	0.92	N.A.		14.69	< 0.01	14.30	< 0.01
CYP2C193*	N.A.		N.A.		18.22	< 0.01	9.98	< 0.01
CYP2D64*	0.01	0.92	N.A.		20.87	< 0.01	18.55	< 0.01
CYP2D610* (100C>T)	24.00	< 0.01	7.39	< 0.01	31.00	< 0.01	27.00	< 0.01
CYP2D610* (4180G>C)	13.67	< 0.01	N.A.		11.94	< 0.01	38.00	< 0.01
CYP2D617* (1023C>T)	11.90	< 0.01	7.00	< 0.01	0.45	0.5	35.34	< 0.01
CYP2D617* (2850C>T)	7.35	< 0.01	10.00	< 0.01	37.66	< 0.01	30.03	< 0.01
CYP3A41B*	N.A.		N.A.		N.A.		24.00	< 0.01
CYP3A53*	1.98	0.16	6.39	0.01	13.36	< 0.01	18.74	< 0.01
N.A.T25*	8.41	< 0.01	3.32	0.07	13.83	< 0.01	13.70	< 0.01
N.A.T26*	N.A.		N.A.		33.29	< 0.01	12.04	< 0.01
N.A.T27*	9.97	< 0.01	8.63	< 0.01	30.21	< 0.01	24.82	< 0.01
N.A.T214*	N.A.		N.A.		32.08	< 0.01	19.30	< 0.01

χ² indicates the result from the Hardy-Weinberg equilibrium test, P the one-tailed P-value, and N.A. that Chi-square could not be calculated because the allele frequency was either 0% or 100%.

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ISSN: 1475-2875

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