Comparison of angiopoietin-1 and -2 levels in whole blood samples from Thai adults with malaria. A-C. Whole blood concentrations of (A) angiopoietin-2 (ANG-2), (B) angiopoietin-1 (ANG-1), and (C) the ratio of ANG-2:ANG-1 (Ratio, expressed as log base 10) were measured in 70 uncomplicated malaria (UM) patients, 36 severe malaria (SM) patients, and 87 cerebral malaria (CM) patients. ***p < 0.0001 by Kruskal-Wallis test with posthoc comparisons using Mann-Whitney U test and Bonferonni correction. D-F. Receiver operating characteristic (ROC) curves were generated for each test to compare (D) UM with SM patients, (E) UM with CM patients, and (F) SM with CM patients, with the null hypothesis (diagonal line) that the area under the curve equals 0.5.