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Table 2 A summary of the results obtained from the final model and the bootstrap analysis.

From: Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects

Parameter Estimate %RSE Bootstrap estimate (95% CI)
CL/F (L/h) 1190 4.20 1176 (1060 -- 1280)
V2/F (L) 1210 5.77 1199 (1020 -- 1370)
Ka (h-1) 3.85 3.61 4.16 (2.66 -- 6.67)
CLM/F (L/h) 93.7 3.30 92.6 (86.5 -- 99.1)
V3/F (L) 97.1 4.85 96.5 (86.7 -- 107)
Q/F (L/h) 5.74 12.8 5.69 (3.72 -- 7.53)
V4/F (L) 18.5 10.6 18.7 (14.1 -- 23.2)
θFOOD-Ka -0.84 2.32 -0.836 (-0.915 -- -0.733)
θWT-CLM/F 1.90 16.3 1.78 (0.993 -- 2.58)
IIV (Variances and % CV)    
   IIV-CL/F 0.131 (36.2) 17.8 0.130 (0.0824 -- 0.176)
   IIV-V2/F 0.330 (57.4) 20.9 0.347 (0.201 -- 0.497)
   IIV-Ka 1.26 (112) 15.4 1.32 (0.751 -- 2.00)
   IIV-CLM/F 0.0786 (28.0) 22.5 0.0740 (0.0411 -- 0.118)
   IIV-V3/F 0.0901 (30.0) 36.0 0.0776 (0.0001 -- 0.151)
RV (%CV)    
   AS 37.5 9.73 37.5 (31.0 -- 45.2)
   DHA 28.2 11.2 27.7 (21.6 -- 34.8)
  1. RSE, relative standard error; CL/F, apparent clearance for AS; F, unknown bioavailability; V2/F, apparent volume of distribution of the central compartment for AS; Ka, absorption rate constant for AS, CLM/F, apparent clearance for DHA from the central compartment; V3/F, apparent central volume of distribution for DHA; Q/F, inter-compartmental clearance for DHA; V4/F, apparent peripheral volume of distribution for DHA; θFOOD-Ka, parameter for the covariate food intake on Ka; θWT-CLM/F, parameter for the covariate weight on CLM/F; CV, coefficient of variation; IIV, inter-individual variability; RV, residual variability; AS, artesunate; DHA, dihydroartemisinin.