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Figure 1 | Malaria Journal

Figure 1

From: Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data

Figure 1

The relationship between a protective immune response and reduction in risk of a defined malaria endpoint. If the risk of a defined malaria endpoint (infection or disease) is inversely related to a vaccine-induced immune response, it may be possible to describe this relationship graphically. Three hypothetical relationships are shown above. The blue dashed line represents a relationship for which a clear threshold could be calculated using efficacy trial data, but in a biological system such a relationship is perhaps less likely than the dotted green and solid red lines.

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