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Table 1 Relative frequencies of polymorphic Pfrct gene SNPs according to villages, ages and years

From: Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger

 

Number of samples

Overall

Banizoumbou vs Zindarou

Adults vs under 15

2003 vs 2006

pfcrtMet74IIe

87

10.3%

11.1% vs 9.5%

(p = 1.0)

22.2% vs 7.1%

(p = 0.084)

0.0% vs 21.4%

(p = 0.001)*

pfcrtLys76Thr

318

32.4%

38.3%vs 25.2%

(p = 0.013)*

37.8% vs 31.5%

(p = 0.405)

20.0% vs 44.4%

(p = 0.013) *

pfcrtHis97gln

87

11.5%

15.6% vs 7.1%

(p = 0.317)

16.7% vs 10.1%

(p = 0.425)

2.2% vs 21.4%

(p = 0.006)

pfcrtAla220Ser

77

10.4%

10.0% vs 10.8%

(p = 1.0)

25.0% vs 6.5%

(p = 0.053)

0.0% vs 19.5%

(p = 0.006)*

  1. in bold p < 0.05
  2. * link kept in logistical regression model)
  3. Global trend for samples from 2003 to 2006 years for pfcrt76 SNP gene