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Table 2 Relative frequencies of polymorphic Pfdhfr gene SNPs according to villages, ages and years

From: Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger

  Number of samples Overall Banizoumbou vs Zindarou Adults vs under 15 2003 vs 2006
pfdhfrAsn51IIe 85 21.2% 22.7% vs 19.5%
(p = 0.717)
23.5% vs 20.6%
(p = 0.75)
9.3% vs 33,3%
(p = 0.008)
pfdhfr Cys59Arg 56 76.7% 80.0% vs 73.1%
(p = 0.541)
77.8% vs 76.6%
(p = 0.939)
73.9% vs 78,8%
(p = 0.671)
pfdhfrSer108Ans 286 53.8% 58.4% vs 46.9%
(p = 0.057)
40.0% vs 56.1%
(p = 0.058)*
21.7% vs 45.7%
(p = 0.015)*
51,59 56 23.2% 20.0% vs 26.9%
(p = 0.541)
44.4% vs 19.1%
(p = 0.189)
4.3% vs 36.4%
(p = 0.008)*
51, 108 81 11.1% 12.2% vs 10.0%
(p = 1.0)
14.3% vs 10.4%
(p = 0.65)
4.7% vs 18.4%
(p = 0.076)
59,108 56 30.3% 40.0% vs 19.2%
(p = 0.092)
33.3% vs 29.8%
(p = 1.0)
7.4% vs 39.4%
(p = 0.139)
51, 59,108 56 11.8% 13.3% vs 11.5%
(p = 1.0)
22.2% vs 18.2%
(p = 0.312)
0% vs 21.2%
(p = 0.034)
  1. in bold p < 0.05
  2. * link kept in logistical regression model)
  3. Samples from 2003 to 2006 years for pfdhfr108 SNP gene