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Table 2 Relative frequencies of polymorphic Pfdhfr gene SNPs according to villages, ages and years

From: Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger

 

Number of samples

Overall

Banizoumbou vs Zindarou

Adults vs under 15

2003 vs 2006

pfdhfrAsn51IIe

85

21.2%

22.7% vs 19.5%

(p = 0.717)

23.5% vs 20.6%

(p = 0.75)

9.3% vs 33,3%

(p = 0.008)

pfdhfr Cys59Arg

56

76.7%

80.0% vs 73.1%

(p = 0.541)

77.8% vs 76.6%

(p = 0.939)

73.9% vs 78,8%

(p = 0.671)

pfdhfrSer108Ans

286

53.8%

58.4% vs 46.9%

(p = 0.057)

40.0% vs 56.1%

(p = 0.058)*

21.7% vs 45.7%

(p = 0.015)*

51,59

56

23.2%

20.0% vs 26.9%

(p = 0.541)

44.4% vs 19.1%

(p = 0.189)

4.3% vs 36.4%

(p = 0.008)*

51, 108

81

11.1%

12.2% vs 10.0%

(p = 1.0)

14.3% vs 10.4%

(p = 0.65)

4.7% vs 18.4%

(p = 0.076)

59,108

56

30.3%

40.0% vs 19.2%

(p = 0.092)

33.3% vs 29.8%

(p = 1.0)

7.4% vs 39.4%

(p = 0.139)

51, 59,108

56

11.8%

13.3% vs 11.5%

(p = 1.0)

22.2% vs 18.2%

(p = 0.312)

0% vs 21.2%

(p = 0.034)

  1. in bold p < 0.05
  2. * link kept in logistical regression model)
  3. Samples from 2003 to 2006 years for pfdhfr108 SNP gene