Skip to main content

Table 3 Relative frequencies of polymorphic Pfdhps gene SNPs according to villages, ages and years

From: Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger

  Number of samples Overall Banizoumbou vs Zindarou Adults vs under 15 2003 vs 2006
pfdhpsSer436Phe 84 71.4% 73.8% vs 69.0%
(p = 0.629)
52.9% vs 76.1%
(p = 0.059)
76.2% vs 66.7%
(p = 0.334)
pfdhpsAla437Gly 49 73.4% 71.0% vs 77.8%
(p = 0.743)
50.0% vs 79.5%
(p = 0.06)
77.3% vs 70.4%
(p = 0.586)
pfdhpsAla581Gly 79 10.1% 19.0% vs 0.0%
(p = 0.006)*
12.5% vs 9.5%
(p = 0.661)
0.0% vs 20.5%
(p = 0.002)*
pfdhpsAla640Thr 90 97.8% 95.6% vs 100.0%
(p = 0.494)
100.0% vs 97.1%
(p = 1.0)
100.0% vs 95.5%
(p = 0.236)
436, 437 49 61.2% 61.3% vs 61.1%
(p = 0.99)
30.0% vs 69.2%
(p = 0.033)
68.2% vs 55.6%
(p = 0.367)
436, 437, 581 48 10.4% 16.1% vs 0.0%
(p = 0.146)
10.0% vs 10.5%
(p = 1.0)
0.0% vs 19.2%
(p = 0.054)
436, 437, 640 48 58.3% 56.7% vs 61.1%
(p = 0.762)
30.0% vs 65.8%
(p = 0.07)*
50.0% vs 68.2%
(p = 0.203)
436, 437,581, 640 47 10.6% 16.7% vs 0.0%
(p = 0.143)
10.0% vs 10.8%
(p = 1.0)
0.0% vs 20.0%
(p = 0.052)
  1. in bold p < 0.05
  2. * link kept in logistical regression model