Table 2 Individual dhfr and dhps mutations by treatment and treatment outcome
Total SP | SP | Total SP-AS | SP-AS | Total | |||
|---|---|---|---|---|---|---|---|
Treatment success | Treatment failure | Treatment success | Treatment failure | ||||
N = 38# | N = 24# | N = 14 | N = 27* | N = 23* | N = 4 | N = 65#* | |
dhfr | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) |
Arg-59 | |||||||
Wild | 1 (2.8) | 1 (4.5) | 0 (0) | 3 (11.5) | 2 (9.1) | 1 (25) | 4 (6.5) |
Mutant | 25 (69.4) | 16 (72.7) | 9 (64.3) | 18 (69.2) | 15 (68.2) | 3 (75) | 43 (69.4) |
Mixed | 10 (27.8) | 5 (22.7) | 5 (35.7) | 5 (19.2) | 5 (22.7) | 0 (0) | 15 (24.2) |
dhps | |||||||
Gly-437 | |||||||
Wild | 4 (11.1) | 2 (9.1) | 2 (14.3) | 1 (3.8) | 1(4.5) | 0 (0) | 5 (8.1) |
Mutant | 30 (83.3) | 19 (86.4) | 11 (78.6) | 24 (92.3) | 20 (90.9) | 4 (100) | 54 (87.1) |
Mixed | 2 (5.6) | 1 (4.5) | 1 (7.1) | 1 (3.8) | 1(4.5) | 0 (0) | 3 (4.8) |
Glu-540 | |||||||
Wild | 33 (91.7) | 21 (95.5) | 12 (85.7) | 26 (100) | 22 (100) | 4 (100) | 59 (95.2) |
Mutant | 3 (8.3) | 1 (4.5) | 2 (14.3) | 0 (0) | 0 (0) | 0 (0) | 3 (4.8) |
Mixed | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |