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Table 2 Severe malaria and TLR9 allelic-based association analysis

From: TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression

  

The Gambia

Malawi

Case-control

alleles

OR1

95% CI2

p-value3

OR

95% CI

p-value3

rs187084

C vs T

0.98

0.82

1.16

0.81

0.82

0.66

1.01

0.06

rs5743836

C vs T

0.92

0.78

1.07

0.26

0.90

0.75

1.08

0.26

rs352139

A vs G

1.08

0.93

1.25

0.33

1.21

1.01

1.45

0.04

rs352140

T vs C

1.03

0.87

1.21

0.77

0.82

0.68

1.00

0.05

Trios

         

rs187084

C vs T

0.95

0.82

1.11

0.55

0.91

0.66

1.26

0.56

rs5743836

C vs T

0.95

0.78

1.16

0.62

0.82

0.59

1.16

0.26

rs352139

A vs G

0.92

0.82

1.05

0.22

1.07

0.77

1.49

0.67

rs352140

T vs C

1.00

0.87

1.16

0.97

0.99

0.72

1.36

0.94

  1. 1OR = odds ratio,
  2. 2 CI = confidence interval
  3. 3 for the trios these are TDT p-values
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Malaria Journal

ISSN: 1475-2875

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