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Table 2 Median (range) doses of artesunate and amodiaquine, expressed as mg/kg, administered on Day 0

From: The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum

Age* AS/AQ (fixed) N = 373 AS+AQ (loose) N = 375
AS
median (range)
AQ
median (range)
AS
median (range)
AQ
median (range)
0–11 months 3.57 (2.50 – 5.56) N = 54 9.64 (6.75 – 15.00) N = 54 3.57 (2.50 – 6.85) N = 59 10.86 (7.60 – 20.96) N = 59
12+ months 4.67 (1.79 – 10.00) N = 319† 12.62 (4.82 – 27.00) N = 319† 4.72 (2.50 – 10.00) N = 316 14.44 (7.65 – 30.60) N = 316
  1. * Median doses for AS and AQ were significantly (p < 0.0001) higher comparing children <12 vs. ≥ 12 months.
  2. † The weights of 2 patients (19 months old and 42 months old) assigned to the AS/AQ treatment group were not available. Both patients received 2 tablets at 25/67.5 mg each on D0