Table 2 Disulfide linkages in CSA-binding DBL domains
| Â | Strain and DBL domain | Disulfide linkages based on A4 DBL 3X | Additional predicted disulfides | Likely free cystein(s) |
|---|---|---|---|---|
| Â | A4 3X crystal structure | 8 | - | None |
1 | 3D7 3X | 7 | - | 2 (C1212, C1558) |
2 | 3D7 2X | 4 | C793 and C920 | 10 (C540, C543, C592, C732, C733, C786, C797, C815, C855, C901) |
3 | A4 2X | 3 | C795 and C910 C817 and C877 | 9 (C544, C547, C599, C617, C734, C788, C799, C807, C929) |
4 | 3D7 5ε | 3 | C2004 and C2041 | 2 (C1995, C2165) |
5 | A4 5ε | 3 | C2010 and C2047 | 2 (C2001, C2171) |
6 | 3D7 6ε | 3 | - | 7 (C2334, C2385, C2480, C2539, C2602, C2604, C2625) |
7 | A4 6ε | 3 | - | 8 (C2331, C2383, C2478, C2493, C2535, C2597, C2599, C2628) |