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Table 2 Analytical methods used to generate estimates of anti-malarial drug efficacy.

From: The effect of varying analytical methods on estimates of anti-malarial clinical efficacy

  Outcome Category Unadjusted by genotyping Adjusted by genotyping
   ITT mITT PP ITT mITT PP
  Follow-up interrupted Failure Censored Excluded Failure Censored Excluded
  ACPR Success Success Success Success Success Success
  ETF Failure Failure Failure Failure Failure Failure
LCF and LPF Recrudescence Failure Failure Failure Failure Failure Failure
  P. falciparum new infection Failure Failure Failure Success Censored Excluded
  Genotyping unsuccessful Failure Failure Failure Failure Excluded Excluded
  Non-falciparum new infection Success Censored Excluded Success Censored Excluded
  1. ITT = intention-to-treat; mITT = modified intention-to-treat; PP = per protocol
  2. ACPR = adequate clinical and parasitological response; ETF = early treatment failure; LCF = late clinical failure; LPF = late parasitological failure
  3. Note: Although the general principles behind these analytical approaches are well-described, in practice differences arise in the way in which the outcome measures may be classified, depending on the rationale of the study. The Table reflects only one set of options and is not definitive for all antimalarial studies.