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Table 4 Stepwise genotyping of msp2 and msp1 in paired samples collected from children with uncomplicated P. falciparum malaria participating in an anti-malarial drug trial in Zanzibar.

From: Optimization and validation of multi-coloured capillary electrophoresis for genotyping of Plasmodium falciparum merozoite surface proteins (msp1 and 2)

   

msp2

msp1

Outcome

Child (study ID)

Daya

FC27b

ICb

K1b

MAD20b

RO33b

Recrudescences

K152

0

-

599.84

505.26

-

-

157.51

 

K152

21

-

599.76

-

-

157.50

 

K97

0

-

559.63

246.15

-

-

 

K97

21

-

559.62

246.05

-

-

 

M107

0

-

523.93

-

220.00

-

 

M107

21

-

523.93

-

220.00

-

 

M131

0

-

487.40

-

202.01

-

 

M131

21

-

487.33

-

202.01

-

 

M152

0

-

528.70

219.25

-

-

 

M152

21

-

528.61

219.26

-

-

New infections

K108

0

336.25

515.38

-

-

157.53

 

K108

42

336.25

-

246.43

-

-

 

K149

0

336.30

452.49

182.77

201.89

-

 

K149

28

336.24

580.85

300.79

210.91

-

 

M161

0

336.30

531.02

138.73

146.36

210.81

220.07

-

 

M161

21

335.75

419.85

622.87

182.72

210.17

192.88

157.62

 

M164

0

336.30

419.71

632.64

620.97

228.45

-

-

 

M164

28

336.30

560.93

255.70

264.91

-

157.53

 

M165

0

335.91

373.27

464.33

210.07

210.81

157.61

 

M165

28

372.97

419.71

-

228.28

-

-

 

M173

0

372.85

531.85

246.31

220.0

228.15

-

 

M173

42

372.14

499.35

564.54

201.10

264.10

246.88

-

  1. Outcome classified by msp2 followed by msp1 genotyping to confirm recrudescence (bold) or new infection.
  2. a Paired blood samples collected before initiation of anti-malarial treatment (day 0) and at day of recurrent parasitaemia (days 21–42)
  3. b Fragment sizes in bp
  4. - negative result
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Malaria Journal

ISSN: 1475-2875

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