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Table 1 EC50, EC99 and cut-off concentrations of pyronaridine, chloroquine, artesunate and quinine in WHO microtest and HRP-2 assay

From: In vitro activity of pyronaridine against Plasmodium falciparum and comparative evaluation of anti-malarial drug susceptibility assays

  WHO Microtest HRP-2 assay
  N EC50 (95%CI) Cut-off concentration (95%CI) N EC50 (95% CI) EC99 (95%CI)
Pyronaridine 32 1.87
(1.40–2.48)
9.32
(5.2–13.9)
15 2.03
(1.57–2.63)
9.03
(6.42–12.69)
Chloroquine 36 7.1
(5.2–9.6)
21.7
(15.4–30.6)
16 5.5
(4.4–6.9)
19.2
(15.3–24.2)
Artesunate 34 2.08
(1.48–2.92)
9.24
(6.53–13.06)
12 2.25
(1.70–2.99)
15.24
(10.45–22.24)
Quinine 32 272
(210–353)
873
(723–1053)
14 204
(167–250)
662
(561–781)
  1. All values are in nmol/l BMM except for chloroquine (μmol/l blood),
  2. Means and 95% confidence intervals are depicted as antilog of arithmetic mean of log-transformed data