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Table 1 EC50, EC99 and cut-off concentrations of pyronaridine, chloroquine, artesunate and quinine in WHO microtest and HRP-2 assay

From: In vitro activity of pyronaridine against Plasmodium falciparum and comparative evaluation of anti-malarial drug susceptibility assays

 

WHO Microtest

HRP-2 assay

 

N

EC50 (95%CI)

Cut-off concentration (95%CI)

N

EC50 (95% CI)

EC99 (95%CI)

Pyronaridine

32

1.87

(1.40–2.48)

9.32

(5.2–13.9)

15

2.03

(1.57–2.63)

9.03

(6.42–12.69)

Chloroquine

36

7.1

(5.2–9.6)

21.7

(15.4–30.6)

16

5.5

(4.4–6.9)

19.2

(15.3–24.2)

Artesunate

34

2.08

(1.48–2.92)

9.24

(6.53–13.06)

12

2.25

(1.70–2.99)

15.24

(10.45–22.24)

Quinine

32

272

(210–353)

873

(723–1053)

14

204

(167–250)

662

(561–781)

  1. All values are in nmol/l BMM except for chloroquine (μmol/l blood),
  2. Means and 95% confidence intervals are depicted as antilog of arithmetic mean of log-transformed data
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Malaria Journal

ISSN: 1475-2875

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