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Table 1 Magnitude of Hb reduction, peak reticulocyte count and peak parasitaemia in the semi-immune mice strain on day minimum Hb was observed

From: Rate of red blood cell destruction varies in different strains of mice infected with Plasmodium berghei-ANKA after chronic exposure

Parameters

Balb/c

B6

NZW

CBA

P valuea

n

11

11

8

12

-

Mean Hb reduction (95% CI)

47.11b (38.12–56.1)

28.44 (22.82–34.1)

30.05 (16.61–43.5)

25.1 (13.97–36.2)

0.037

Mean Parasitaemia, % (95% CI)

0.64c (0.2–1.1)

3.3 (1.6–4.9)

7.5 (5.0–10.1)

3.1 (0.98–6.25)

< 0.0001

Mean Reticulocyte level, % (95% CI)

12.45d (8.9–15.97)

3.2 (1.9–4.4)

2.0 (0.6–3.4)

3.1 (1.4–4.8)

0.0016

Mean of Reticulocyte level/Hb reduction

0.24e

0.11

0.07

0.12

0.003

Mean Period, day (95% CI) at which Hbm was observed

13.64d (12.13–15.15)

10.6 (9.95–11.33)

10.86 (9.2–12.5)

10.9 (10.3–11.5)

0.014

  1. Hb reduction is the difference between %Hb on day prior to first cycle infection and treatment, and day on which Hbm was observed (blood harvested for serum). The data presented here are pooled results of two separate experiments. aOne-way ANOVA with Tukey's post-test. bSignificantly higher than CBA; Significantly c lower, dhigher than B6, NZW, CBA; eSignificantly higher than B6, NZW. Hbm, minimum Hb.