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Table 1 Pharmacokinetic parameters of artemether, dihydroartemisinin (DHA) and lumefantrine (mean or mean ± SD) among healthy volunteers and patients with malaria receiving a six-dose, three-day regimen of AL

From: Understanding the pharmacokinetics of Coartem®

    Pharmacokinetic parameters
   Artemether DHA
Subjects (n) Food or fat content (g) Country/Area Cmax (ng/mL) AUC (μg·h/mL) t1/2 (h) Cmax (ng/mL) AUC (μg·h/mL) t1/2 (h)
Healthy volunteers (n = 14) [22] ~65 ga Europe 30.8 ± 25.4 61.4 ± 87.5 2.0 ± 1.2 84.5 ± 26.5 178 ± 71 1.2 ± 0.4
Malaria patients (n = 13) [6] 7 gd Thailand 34.8 66.4 1.5 165 367 1.3
Malaria patients Local Thailand 66.2 ± 54.3 211 ± 109 2.2 ± 1.0 205 ± 102 604 ± 259 1.6 ± 0.4
    Lumefantrine
Subjects (n) Food or fat content (g) Country/Area C max (μg/mL) AUC (μg·h/mL) t 1/2 (day) Day 7 concentration (ng/mL)
Healthy volunteers (n = 14) [22] ~65 ga Europe 10.0 ± 5.5 383 ± 304e 6.0 ± 1.3 -
Malaria patients (n = 266) [7] Local standard food Thailand 9.0 561 3.2 -
Malaria patients (n = 74) [13] 23 gb Uganda 5.6 ± 2.7 - - 460 ± 288
Malaria patients (n = 17) [9] 6.4 gc Thailand 7.0 410 4.1 350
Malaria patients (n = 13) [6] 7 gd Thailand 7.34 252f 2.83 384
  1. aFDA breakfast = 2 eggs, 2 strips bacon, 1 slice of toast with butter, 2 hash potatoes, 240 mL full-fat milk; b10 g (300 mL milk) + 13 g (peanuts) or breast milk; c200 mL carton chocolate milk; d250 mL chocolate milk; eAUC62 h-last; fAUC60 h-∞