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Table 5 In vitro IC50 for hERG tail current in HEK 293 cells and cardiac safety index of antimalaria drugs [52]

From: Safety profile of Coartem®: the evidence base

Agent

IC50 - IKr (μM)

IC50/therapeutic free plasma concentration*

Halofantrine

0.04

0.07

Chloroquine

2.5

6.3

Mefloquine

2.6

50

Desbutyl-lumefantrine

5.5

~2,900

Lumefantrine

8.1

48

  1. * Cardiac safety index. Values greater than 30 suggest cardiotoxicity is unlikely
  2. hERG: human ether-a-go-go related gene; IC50: inhibitory concentration 50 (the concentration that gives 50% inhibition)