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Table 5 In vitro IC50 for hERG tail current in HEK 293 cells and cardiac safety index of antimalaria drugs [52]

From: Safety profile of Coartem®: the evidence base

Agent IC50 - IKr (μM) IC50/therapeutic free plasma concentration*
Halofantrine 0.04 0.07
Chloroquine 2.5 6.3
Mefloquine 2.6 50
Desbutyl-lumefantrine 5.5 ~2,900
Lumefantrine 8.1 48
  1. * Cardiac safety index. Values greater than 30 suggest cardiotoxicity is unlikely
  2. hERG: human ether-a-go-go related gene; IC50: inhibitory concentration 50 (the concentration that gives 50% inhibition)