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Table 6 Most frequently reported adverse events that occurred at a frequency of >10% in either group of patients enrolled in comparator studies [7, 8, 52]

From: Safety profile of Coartem®: the evidence base

Adverse event preferred term AL n(%) n = 314 MAS n(%) n = 105
Pyrexia 183 (58.3) 63 (60.0)
Headache 166 (52.9) 46 (43.8)
Dizziness 123 (39.2) 37 (35.2)
Anorexia 108 (34.4) 37 (35.2)
Asthenia 108 (34.4) 33 (31.4)
Arthralgia 99 (31.5) 31 (29.5)
Nausea 82 (26.1) 34 (32.4)
Myalgia 74 (23.6) 19 (18.1)
Sleep disorder 70 (22.3) 30 (28.6)
Chills 67 (21.3) 20 (19.0)
Vomiting 50 (15.9) 22 (21.0)
Abdominal pain 61 (19.4) 20 (19.0)
Palpitation 55 (17.5) 17 (16.2)
Hepatomegaly 48 (15.3) 8 (7.6)
Splenomegaly 40 (12.7) 12 (11.4)
Fatigue 34 (10.8) 8 (7.6)
  1. AL: artemether/lumefantrine; MAS: mefloquine/artesunate