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Figure 2 | Malaria Journal

Figure 2

From: Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression

Figure 2

Mouse experiments with malarial infection: experiment and 1H NMR based OPLS-DA of serum and brain. A. The experiment consisted of 12 males and 12 females. The parasite P. berghei ANKA was injected in 8 males and 8 females on day 0. On day 5 post-infection, 4 uninfected controls (2 males, 2 females) and 8 infected animals (4 males, 4 females) were sacrificed and whole brain tissue and serum collected. The remaining animals were sacrificed similarly on day 13 post-infection. B. Scores plot of the OPLS-DA model of serum and brain from all 24 animals showing male-female class separation. R2X(cum), Q2(cum) = 0.506, -0.156 serum; 0.564, -0.278 brain. Temporal metabolic changes in C. serum and D. brain have been shown by comparing day 5 (early) and day 13 (late) post-infection with uninfected controls. C. R2X(cum), Q2(cum) = 0.87, 0.531 males, early; 0.994, 0.983 males, late; 0.744, -0.241 females, early; 0.996, 0.977 females, late D. R2X(cum), Q2(cum) = 0.554, 0.08 males, early; 0.981, 0.991 males, late; 0.698, -0.199 females, early; 0.985, 0.933 females, late.

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