General trend of the Inflammatory profile in vivax malaria. Plasma levels of (A) TNF, (B) IFN-gamma, (C) IL-10 and (D) IFN-gamma/IL-10 ratios were estimated in non-infected individuals and those presenting different manifestations of the vivax malaria clinical spectrum. Study participants were stratified in groups as follows: non-infected (NI; n = 90); asymptomatic infection (Asy; n = 60); mild infection (Mild; n = 50); and severe infection (Sev; n = 19). One-Way ANOVA with trend analysis was performed to check the statistical significance between the groups studied. P values are plotted in each graph.