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Table 3 The duration of gametocyte carriage and persistence of gametocytes after treatment with non-ACT, ACT and ACT-PQ in clinical trials in Kenya and Tanzania.

From: Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

  Duration of gametocyte carriage in days (95% CI) % still gametocytaemic during follow up (n/N)
  Day 14 Day 28
Kenya, 2003-2004    
Non-ACT 55.6 (28.7-107.7) 77.8 (28/36) 48.3 (14/29)
ACT 13.4 (10.2-17.5) 55.6 (50/90) 11.9 (10/84)
p-value < 0.001 0.02 < 0.001
Tanzania, 2006    
ACT 28.6 (17.0-48.0) 58.3% (21/36) 38.9% (14/36)
ACT-PQ 6.3 (4.7-8.5) 4.9%(2/41) 12.2% (5/41)
p-value < 0.001 < 0.001 0.007
  1. All individuals included in the analyses had gametocytes by Pfs25 QT-NASBA at enrolment and were successfully treated, i.e. were free of microscopic asexual parasitaemia between day 3 and the end of follow-up.