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Table 3 The duration of gametocyte carriage and persistence of gametocytes after treatment with non-ACT, ACT and ACT-PQ in clinical trials in Kenya and Tanzania.

From: Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

 

Duration of gametocyte carriage in days (95% CI)

% still gametocytaemic during follow up (n/N)

 

Day 14

Day 28

Kenya, 2003-2004

   

Non-ACT

55.6 (28.7-107.7)

77.8 (28/36)

48.3 (14/29)

ACT

13.4 (10.2-17.5)

55.6 (50/90)

11.9 (10/84)

p-value

< 0.001

0.02

< 0.001

Tanzania, 2006

   

ACT

28.6 (17.0-48.0)

58.3% (21/36)

38.9% (14/36)

ACT-PQ

6.3 (4.7-8.5)

4.9%(2/41)

12.2% (5/41)

p-value

< 0.001

< 0.001

0.007

  1. All individuals included in the analyses had gametocytes by Pfs25 QT-NASBA at enrolment and were successfully treated, i.e. were free of microscopic asexual parasitaemia between day 3 and the end of follow-up.