Table 2 Differentially expressed proteins in DOX-treated parasites (iTRAQ quantification).
From: Plasmodium falciparum proteome changes in response to doxycycline treatment
Accession numbera | Name | Peptides quantified | Ratios ± SD | Biological processb | Predicted Localizationc |
|---|---|---|---|---|---|
PF13_0130 | Vacuolar ATP synthase subunit g | 3 | 2.47 ± 1.07 | Vacuolar acidification | Membrane |
PFC0735w | 40S ribosomal protein S15A putative | 3 | 1.93 ± 0.71 | Translation | Cytoplasm |
PF08_0074 | DNA/RNA-binding Protein Alba, putative | 6 | 1.82 ± 0.08 | Nucleic acid binding | Nucleus |
MAL13P1.214 | Phosphoethanolamine N-methyltransferase | 6 | 1.79 ± 0.47 | Phosphatidylcholine biosynthesis | Unknown |
PF10_0068 | RNA binding protein putative | 3 | 1.76 ± 0.16 | Nucleic acid binding | Apicoplast |
PFB0340c | Serine repeat antigen 5 (SERA-5) | 8 | 1.76 ± 0.37 | Proteolysis | Unknown |
PFC0920w | Histone H2A variant putative | 3 | 1.59 ± 0.25 | Nucleosome assembly | Apicoplast |
PFI1090w | S-adenosylmethionine synthetase | 5 | 1.57 ± 0.25 | One carbon compound metabolism | Cytoplasm |
PFB0915w | Liver stage antigen-3 | 4 | 1.54 ± 0.04 | Unknown | Membrane |
PFL1545c | Chaperonin cpn60 | 3 | 1.52 ± 0.40 | Protein folding | Apicoplast |
PFF0835w | Conserved Plasmodium protein | 5 | 1.50 ± 0.01 | Unknown | Unknown |
PF08_0110 | Rab18 GTPase | 3 | 1.49 ± 0.13 | Intracellular protein transport | Cytoplasm |
PF14_0078 | Plasmepsin III|HAP protein | 6 | 1.48 ± 0.04 | Haemoglobin Catabolism | Membrane |
PF14_0324 | Hsp70/Hsp90 organizing protein putative | 17 | 1.46 ± 0.21 | Protein folding | Unknown |
PF10_0115 | QF122 antigen | 9 | 1.45 ± 0.04 | Nucleic acid binding | Apicoplast |
PF14_0655 | RNA helicase-1 putative | 5 | 1.44 ± 0.01 | Translation | Cytoplasm |
PF14_0201 | Surface protein putative Pf113 | 6 | 1.44 ± 0.07 | Unknown | Membrane |
PF14_0486 | Elongation factor 2 | 16 | 1.41 ± 0.30 | Translation | Cytoplasm |
PF10_0323 | Early transcribed membrane protein 10.2 | 4 | 1.40 ± 0.08 | Unknown | Membrane |
PFL1170w | Polyadenylate-binding protein putative | 12 | 1.35 ± 0.05 | Transcription | Unknown |
gi|544759 | Biliverdin reductase B | 2 | 1.35 ± 0.16 | Porphyrin metabolism | Cytoplasm |
PFE0870w | Transcriptional regulator putative | 4 | 1.34 ± 0.10 | Transcription | Nucleus |
gi|4506765 | S100 calcium-binding protein A4 | 2 | 1.34 ± 0.06 | Cell growth | Cytoplasm |
PF11_0062 | Histone H2B | 7 | 1.34 ± 0.12 | Nucleosome assembly | Apicoplast |
PF14_0391 | 60S ribosomal protein L1 putative | 2 | 1.32 ± 0.13 | Translation | Cytoplasm |
MAL8P1.69 | 14-3-3 protein | 6 | 1.30 ± 0.19 | Protein folding | Unknown |
MAL13P1.56 | M1-family aminopeptidase | 5 | 1.28 ± 0.06 | Haemoglobin Catabolism | Apicoplast |
PF14_0439 | Leucine aminopeptidase putative | 4 | 1.27 ± 0.18 | Haemoglobin Catabolism | Apicoplast |
PF08_0096 | RNA helicase putative | 3 | 1.24 ± 0.04 | Transcription | Unknown |
PF08_0131 | 1-Cys peroxiredoxin | 9 | 1.22 ± 0.15 | Anti oxidative stress | Unknown |
PFE0585c | Myo-inositol 1-phosphate synthase putative | 10 | 1.22 ± 0.03 | Phospholipid biosynthetic process | Unknown |
PFL1720w | Serine hydroxymethyltransferase | 3 | 1.21 ± 0.01 | One carbon compound metabolism | Unknown |
PF14_0167 | Prefoldin subunit 2 putative | 4 | 0.80 ± 0.05 | Protein folding | Cytoplasm |
PFI1780w | Plasmodium exported protein (PHISTc) | 2 | 0.80 ± 0.19 | Unknown | Apicoplast |
MAL8P1.95 | Conserved Plasmodium protein | 5 | 0.76 ± 0.09 | Unknown | Unknown |
PFE0290c | Conserved Plasmodium protein | 3 | 0.75 ± 0.06 | Unknown | Unknown |
PFA0110w | DnaJ protein putative | 5 | 0.74 ± 0.24 | Protein folding | Membrane |
PF08_0087 | Importin alpha putative | 5 | 0.73 ± 0.12 | Nucleus transport | Nucleus |
PFD0090c | Plasmodium exported protein (PHISTa) | 4 | 0.61 ± 0.14 | Unknown | Apicoplast |
PF11_0351 | Heat shock protein hsp70 homologue | 6 | 0.54 ± 0.04 | Protein folding | Mitochondrion |