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Figure 2 | Malaria Journal

Figure 2

From: Comparison of Plasmodium berghei challenge models for the evaluation of pre-erythrocytic malaria vaccines and their effect on perceived vaccine efficacy

Figure 2

Analysis of failed IV challenge experiments. Failed (i.e., less than 90% of naïve mice challenged with 300 SPZ became infected) challenge experiments showed one of two titration patterns. Type 1 challenge failures (dotted line) showed a direct relationship between sporozoites dose and percent of mice infected. Type 2 failures (solid line) showed an inverse relationship between sporozoites dose and the percentage of mice infected. N = 10 mice/group for each experiment. Shown are the average numbers of infected animals from independent challenge experiments ± SEM.

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